Gene Symbol: AKT1
Description: AKT serine/threonine kinase 1
Alias: AKT, RAC-alpha serine/threonine-protein kinase, PKB alpha, RAC-PK-alpha, protein kinase B alpha
Species: cow
Products:     AKT1

Top Publications

  1. Coffer P, Woodgett J. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem. 1991;201:475-81 pubmed
    ..Column fractions containing PKB-immunoreactive protein exhibited elevated histone H1 kinase activity compared with similar fractions from control cells, demonstrating the enzymatic activity of this protein kinase. ..
  2. van den Heuvel A, de Vries Smits A, Van Weeren P, Dijkers P, de Bruyn K, Riedl J, et al. Binding of protein kinase B to the plakin family member periplakin. J Cell Sci. 2002;115:3957-66 pubmed
    The serine/threonine kinase protein kinase B (PKB/c-Akt) acts downstream of the lipid kinase phosphoinositide 3-kinase (PI3K) and functions as an essential mediator in many growth-factor-induced cellular responses such as cell cycle ..
  3. Coffer P, Woodgett J. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem. 1992;205:1217 pubmed
  4. Jin Z, Wong C, Wu J, Berk B. Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. J Biol Chem. 2005;280:12305-9 pubmed
    ..We showed previously that flow activated the phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric-oxide synthase (eNOS) via Src kinase-dependent transactivation of vascular endothelial ..
  5. Sakamoto K, Yano T, Kobayashi T, Hagino A, Aso H, Obara Y. Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells. Domest Anim Endocrinol. 2007;32:260-72 pubmed
    ..that GH dramatically inhibits the expression of IGFBP-5, and GH along with IGF-I enhanced the phosphorylation of Akt through the reduction of IGF binding protein (IGFBP)-5...
  6. Gao T, Furnari F, Newton A. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005;18:13-24 pubmed
    ..repeat protein phosphatase (PHLPP), that specifically dephosphorylates the hydrophobic motif of Akt (Ser473 in Akt1), triggering apoptosis and suppressing tumor growth...
  7. Li G, Anderson R, Tomita H, Adler R, Liu X, Zack D, et al. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J Neurosci. 2007;27:203-11 pubmed
    ..We investigated the functional roles of Akt1 and Akt2, two of the isoforms of Akt, and their biological significance in light-induced retinal degeneration...
  8. Oviedo Boyso J, Cort s Vieyra R, Huante Mendoza A, Yu H, Valdez Alarc n J, Bravo Pati o A, et al. The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Infect Immun. 2011;79:4569-77 pubmed publisher
    ..Because the phosphoinositide-3-kinase (PI3K)-Akt signaling pathway also modulates NF-?B activity, we considered whether the internalization of S...
  9. Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa W, et al. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene. 2005;24:3954-63 pubmed
    Hsp90 client protein Akt has been shown to inhibit cell apoptosis in part by inhibiting proapoptotic kinase ASK1 (apoptosis signal-regulating kinase 1) activity...

More Information


  1. Penumatsa K, Abualkhair S, Wei L, Warburton R, Preston I, Hill N, et al. Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells. Cell Signal. 2014;26:2818-25 pubmed publisher
    ..distal PASMCs with varying concentrations of the inhibitor MDC led to differential inhibition of 5-HT-stimulated AKT and ROCK activation, while p-P38 was unaffected...
  2. Youn J, Wang T, Cai H. An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res. 2009;104:50-9 pubmed publisher
    ..A rapid membrane colocalization of calpain and ezrin occurred as short as 10 minutes after VEGF stimulation. AKT, AMP-dependent kinase (AMPK), and endothelial nitric oxide synthase (eNOS)(s1179) phosphorylations in VEGF-..
  3. Bodiga S, Gruenloh S, Gao Y, Manthati V, Dubasi N, Falck J, et al. 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. Am J Physiol Lung Cell Mol Physiol. 2010;298:L564-74 pubmed publisher
    ..Activation of endothelial nitric oxide synthase (eNOS) (Ser1179) and Akt (Ser473) was assessed by comparing the ratio of phosphorylated to total protein expression by Western blotting...
  4. Trane A, Hiob M, Uy T, Pavlov D, Bernatchez P. Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling. Eur J Pharmacol. 2015;766:46-55 pubmed publisher
    ..Instead, F92A substitution in CAV(WT) influences Akt activation and downstream eNOS phosphorylation status...
  5. Andrade G, da Silveira J, Perrini C, Del Collado M, Gebremedhn S, Tesfaye D, et al. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. PLoS ONE. 2017;12:e0185045 pubmed publisher
    ..cells (FCs-granulosa and cumulus cells) and cumulus-oocyte complexes (COCs) to investigate whether the PI3K-Akt signaling pathway impacted oocyte quality...
  6. Watanabe T, Suzuki J, Yamawaki H, Sharma V, Sheu S, Berk B. Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. Circulation. 2005;112:1798-805 pubmed
    ..function, we hypothesized that losartan and its metabolites would stimulate eNOS and its upstream activators Akt and phosphatidylinositol 3-kinase (PI3K)...
  7. Arvisais E, Romanelli A, Hou X, Davis J. AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha. J Biol Chem. 2006;281:26904-13 pubmed
    ..Treatment with PGF2alpha did not increase AKT phosphorylation but increased the phosphorylation of Erk and the tumor suppressor protein tuberous sclerosis ..
  8. Lu J, Lu Z, Reinach P, Zhang J, Dai W, Lu L, et al. TGF-beta2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Exp Cell Res. 2006;312:3631-40 pubmed
    ..Whereas FGF-2 stimulates cell proliferation by activating the AKT pathway, TGF-beta2 and PGE-2 both inhibit this pathway...
  9. Yonezawa T, Haga S, Kobayashi Y, Katoh K, Obara Y. Unsaturated fatty acids promote proliferation via ERK1/2 and Akt pathway in bovine mammary epithelial cells. Biochem Biophys Res Commun. 2008;367:729-35 pubmed publisher
    ..Phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and Akt kinase, which regulates cell proliferation and survival, was rapidly increased by oleate...
  10. Fitzgerald T, Shepherd B, Asada H, Teso D, Muto A, Fancher T, et al. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. J Cell Physiol. 2008;216:389-95 pubmed publisher
    ..b>Akt, caspase, bax, and bcl-2 phosphorylation were assessed by Western blotting; caspase activity was also measured with ..
  11. Rovani M, Ilha G, Gasperin B, Nóbrega J, Siddappa D, Glanzner W, et al. Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle. Mol Reprod Dev. 2017;84:486-494 pubmed publisher
    ..and activator of transcription 3 (STAT3) was activated in granulosa cells during follicle atresia, whereas AKT is immediately down-regulated in the corpus luteum after PGF treatment in cattle; however, their involvement in ..
  12. Gerasimovskaya E, Tucker D, Stenmark K. Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation. J Appl Physiol (1985). 2005;98:722-31 pubmed
    ..Previous studies have suggested that ERK1/2, phosphatidylinositol 3-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR) are activated by hypoxia and play a role in a variety of cell responses...
  13. Sen A, Lv L, Bello N, Ireland J, Smith G. Cocaine- and amphetamine-regulated transcript accelerates termination of follicle-stimulating hormone-induced extracellularly regulated kinase 1/2 and Akt activation by regulating the expression and degradation of specific mitogen-activated protein k. Mol Endocrinol. 2008;22:2655-76 pubmed publisher
    ..We also reported that FSH-induced estradiol production is dependent on Erk1/2 and Akt signaling, and CART may regulate other signaling proteins downstream of cAMP essential for estradiol production...
  14. Niwa K, Inanami O, Yamamori T, Ohta T, Hamasu T, Kuwabara M. Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide. Antioxid Redox Signal. 2003;5:713-22 pubmed
    ..H(2)O(2) increased the levels of PI3K activity and Akt phosphorylation...
  15. Gómez B, Gifford C, Hallford D, Hernandez Gifford J. Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle. Anim Reprod Sci. 2015;163:97-104 pubmed publisher
    ..granulosa cells (GC) of cattle, FSH treatment increased protein abundance of CTNNB1 as well as protein kinase B (AKT), a molecule known to regulate components of the CTNNB1 degradation complex...