Gene Symbol: AKR1C4
Description: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Alias: AKR1C1, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), dihydrodiol dehydrogenase 3, prostaglandin F synthase
- A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coliW Kuchinke
Osaka Bioscience Institute, Japan
Biochem Biophys Res Commun 183:1238-46. 1992Using the cDNA of bovine lung prostaglandin F synthase (EC 184.108.40.206) as a probe, we isolated a clone from a bovine liver cDNA library which differed in only eleven nucleotides from the probe...
- Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frogK Watanabe
Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
Proc Natl Acad Sci U S A 85:11-5. 1988..171, 297-302] and of PGF synthase show 77% identical and conservative substitutions without deletions/additions. The result suggests that European common frog lens epsilon-crystallin is identical to bovine lung PGF synthase...
- cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthaseT Suzuki
Second Department, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
J Biol Chem 274:241-8. 1999..Additionally, the 5-fold increase in kcat/Km value of the N306Y mutant for PGH2 compared with the wild-type value suggests that the amino acid at 306 plays an important role in catalytic efficiency for PGH2...
- An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometriumEric Madore
Unité de Recherche en Ontogénie et Reproduction et Département d Obstétrique et Gynécologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Sainte Foy, Quebec G1V 4G2, Canada
J Biol Chem 278:11205-12. 2003..Our objective was to identify which prostaglandin F synthase is involved and to study its regulation in the endometrium and in endometrial primary cell cultures...