AKR1C4

Summary

Gene Symbol: AKR1C4
Description: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Alias: AKR1C1, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), dihydrodiol dehydrogenase 3, prostaglandin F synthase
Species: cow

Top Publications

  1. ncbi A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli
    W Kuchinke
    Osaka Bioscience Institute, Japan
    Biochem Biophys Res Commun 183:1238-46. 1992
  2. pmc Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog
    K Watanabe
    Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
    Proc Natl Acad Sci U S A 85:11-5. 1988
  3. ncbi cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase
    T Suzuki
    Second Department, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 274:241-8. 1999
  4. ncbi An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium
    Eric Madore
    Unité de Recherche en Ontogénie et Reproduction et Département d Obstétrique et Gynécologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 278:11205-12. 2003

Detail Information

Publications4

  1. ncbi A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli
    W Kuchinke
    Osaka Bioscience Institute, Japan
    Biochem Biophys Res Commun 183:1238-46. 1992
    Using the cDNA of bovine lung prostaglandin F synthase (EC 1.1.1.2) as a probe, we isolated a clone from a bovine liver cDNA library which differed in only eleven nucleotides from the probe...
  2. pmc Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog
    K Watanabe
    Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
    Proc Natl Acad Sci U S A 85:11-5. 1988
    ..171, 297-302] and of PGF synthase show 77% identical and conservative substitutions without deletions/additions. The result suggests that European common frog lens epsilon-crystallin is identical to bovine lung PGF synthase...
  3. ncbi cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase
    T Suzuki
    Second Department, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 274:241-8. 1999
    ..Additionally, the 5-fold increase in kcat/Km value of the N306Y mutant for PGH2 compared with the wild-type value suggests that the amino acid at 306 plays an important role in catalytic efficiency for PGH2...
  4. ncbi An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium
    Eric Madore
    Unité de Recherche en Ontogénie et Reproduction et Département d Obstétrique et Gynécologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 278:11205-12. 2003
    ..Our objective was to identify which prostaglandin F synthase is involved and to study its regulation in the endometrium and in endometrial primary cell cultures...