Gene Symbol: AKR1C4
Description: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Alias: AKR1C1, dihydrodiol dehydrogenase 3, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), prostaglandin F synthase
- Kuchinke W, Barski O, Watanabe K, Hayaishi O. A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. Biochem Biophys Res Commun. 1992;183:1238-46 pubmedUsing the cDNA of bovine lung prostaglandin F synthase (EC 18.104.22.168) as a probe, we isolated a clone from a bovine liver cDNA library which differed in only eleven nucleotides from the probe...
- Suzuki T, Fujii Y, Miyano M, Chen L, Takahashi T, Watanabe K. cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase. J Biol Chem. 1999;274:241-8 pubmed..Additionally, the 5-fold increase in kcat/Km value of the N306Y mutant for PGH2 compared with the wild-type value suggests that the amino acid at 306 plays an important role in catalytic efficiency for PGH2. ..
- Madore E, Harvey N, Parent J, Chapdelaine P, Arosh J, Fortier M. An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium. J Biol Chem. 2003;278:11205-12 pubmed..Our objective was to identify which prostaglandin F synthase is involved and to study its regulation in the endometrium and in endometrial primary cell cultures...
- Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, et al. Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Proc Natl Acad Sci U S A. 1988;85:11-5 pubmed..171, 297-302] and of PGF synthase show 77% identical and conservative substitutions without deletions/additions. The result suggests that European common frog lens epsilon-crystallin is identical to bovine lung PGF synthase. ..