Gene Symbol: AKR1C4
Description: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Alias: AKR1C1, dihydrodiol dehydrogenase 3, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), prostaglandin F synthase
Species: cow

Top Publications

  1. Kuchinke W, Barski O, Watanabe K, Hayaishi O. A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. Biochem Biophys Res Commun. 1992;183:1238-46 pubmed
    Using the cDNA of bovine lung prostaglandin F synthase (EC as a probe, we isolated a clone from a bovine liver cDNA library which differed in only eleven nucleotides from the probe...
  2. Suzuki T, Fujii Y, Miyano M, Chen L, Takahashi T, Watanabe K. cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase. J Biol Chem. 1999;274:241-8 pubmed
    ..Additionally, the 5-fold increase in kcat/Km value of the N306Y mutant for PGH2 compared with the wild-type value suggests that the amino acid at 306 plays an important role in catalytic efficiency for PGH2. ..
  3. Madore E, Harvey N, Parent J, Chapdelaine P, Arosh J, Fortier M. An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium. J Biol Chem. 2003;278:11205-12 pubmed
    ..Our objective was to identify which prostaglandin F synthase is involved and to study its regulation in the endometrium and in endometrial primary cell cultures...
  4. Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, et al. Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Proc Natl Acad Sci U S A. 1988;85:11-5 pubmed
    ..171, 297-302] and of PGF synthase show 77% identical and conservative substitutions without deletions/additions. The result suggests that European common frog lens epsilon-crystallin is identical to bovine lung PGF synthase. ..