ABCG2

Summary

Gene Symbol: ABCG2
Description: ATP binding cassette subfamily G member 2
Alias: ATP-binding cassette sub-family G member 2, ATP binding cassette subfamily G member 2 (Junior blood group), ATP binding cassette superfamily G number 2 transporter, ATP-binding cassette superfamily G member 2 transporter protein, ATP-binding cassette transporter subfamily G member 2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ATP-binding cassette, sub-family G, member 2, breast cancer resistance protein, urate exporter
Species: cow
Products:     ABCG2

Top Publications

  1. Tantia M, Vijh R, Mishra B, Mishra B, Kumar S, Sodhi M. DGAT1 and ABCG2 polymorphism in Indian cattle (Bos indicus) and buffalo (Bubalus bubalis) breeds. BMC Vet Res. 2006;2:32 pubmed
    ..to estimate the frequency of K232A (DGAT1--diacylglycerol-acyltransferase 1) and Y581S (ABCG2--ATP binding cassette sub family G member 2) polymorphisms in diverse cattle and buffalo breeds of India having large variation in terms of ..
  2. Braunschweig M. Mutations in the bovine ABCG2 and the ovine MSTN gene added to the few quantitative trait nucleotides identified in farm animals: a mini-review. J Appl Genet. 2010;51:289-97 pubmed publisher
    ..this mini-review, the recent progress in mapping quantitative trait nucleotides (QTNs) are reviewed, including the ABCG2 gene mutation that underlies a QTL for fat and protein content and the ovine MSTN gene mutation that causes ..
  3. Ron M, Cohen Zinder M, Peter C, Weller J, Erhardt G. Short communication: a polymorphism in ABCG2 in Bos indicus and Bos taurus cattle breeds. J Dairy Sci. 2006;89:4921-3 pubmed
    ..nucleotide change (A/C) in exon 14 is capable of encoding a substitution of tyrosine-581 to serine (Y581S) in the ABCG2 (ATP binding cassette, subfamily G, member 2) gene and affects milk production traits...
  4. Wassermann L, Halwachs S, Lindner S, Honscha K, Honscha W. Determination of functional ABCG2 activity and assessment of drug-ABCG2 interactions in dairy animals using a novel MDCKII in vitro model. J Pharm Sci. 2013;102:772-84 pubmed publisher
    The ATP-binding cassette subfamily G member 2 (ABCG2) transporter is a member of the ATP-binding cassette (ABC) family of efflux carriers that mediates cellular extrusion of various drugs and toxins...
  5. Otero J, Miguel V, González Lobato L, García Villalba R, Espín J, Prieto J, et al. Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid. Animal. 2016;10:238-47 pubmed publisher
    The ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP) is an efflux protein involved in the bioavailability and milk secretion of endogenous and exogenous compounds, actively affecting milk composition...
  6. Yue W, Fang X, Zhang C, Pang Y, Xu H, Gu C, et al. Two novel SNPs of the ABCG2 gene and its associations with milk traits in Chinese Holsteins. Mol Biol Rep. 2011;38:2927-32 pubmed publisher
    The ATP-binding cassette transporter ABCG2 (also known as breast cancer resistance protein, BCRP) belongs to the ATP-binding cassette (ABC) family of transmembrane drug transporters, playing a crucial role in the protection of various ..
  7. Wei J, Geale P, Sheehy P, Williamson P. The impact of ABCG2 on bovine mammary epithelial cell proliferation. Anim Biotechnol. 2012;23:221-4 pubmed publisher
    The ATP-binding cassette transporter, ABCG2, has been identified as a gene of significance in the regulation of bovine lactation by a number of gene mapping studies yet its role in lactational physiology remains unclear...
  8. Haslam I, Simmons N. Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen. J Comp Physiol B. 2014;184:673-81 pubmed publisher
    ..the rumen associated with cytoprotection against xenobiotic exposure, namely MDR1 (ABCB1), MRP2 (ABCC2) and BCRP (ABCG2)...
  9. Helms H, Hersom M, Kuhlmann L, Badolo L, Nielsen C, Brodin B. An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1. AAPS J. 2014;16:1046-55 pubmed publisher
    Efflux transporters of the ATP-binding cassette superfamily including breast cancer resistance protein (Bcrp/Abcg2), P-glycoprotein (P-gp/Abcb1) and multidrug resistance-associated proteins (Mrp's/Abcc's) are expressed in the blood-brain ..

More Information

Publications16

  1. Real R, Gonzalez Lobato L, Baro M, Valbuena S, de la Fuente A, Prieto J, et al. Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models. J Anim Sci. 2011;89:4325-38 pubmed publisher
    ..the main determinants of active drug secretion into milk is the ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP)...
  2. Otero J, Real R, de la Fuente A, Prieto J, Marques M, Alvarez A, et al. The bovine ATP-binding cassette transporter ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the fluoroquinolone danofloxacin. Drug Metab Dispos. 2013;41:546-9 pubmed publisher
    The bovine adenosine triphosphate-binding cassette transporter G2 (ABCG2/breast cancer resistance protein) polymorphism Tyr581Ser (Y581S) has recently been shown to increase in vitro transepithelial transport of antibiotics...
  3. Asadollahpour Nanaei H, Ansari Mahyari S, Edriss M. Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle. Reprod Domest Anim. 2014;49:769-74 pubmed publisher
    ..the impact of three polymorphisms located in the ATP-binding cassette superfamily G member 2 transporter (ABCG2), stearoyl-CoA desaturase 1 (SCD1) and leptin receptor (LEPR) genes on reproductive traits and somatic cell count (..
  4. Li C, Sun D, Zhang S, Yang S, Alim M, Zhang Q, et al. Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association study. BMC Genet. 2016;17:110 pubmed publisher
    ..receptor gamma, coactivator 1 alpha (PPARGC1A), ATP-binding cassette, sub-family G, member 2 (ABCG2) and insulin-like growth factor 1 (IGF1) genes...
  5. Olsen H, Nilsen H, Hayes B, Berg P, Svendsen M, Lien S, et al. Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattle. BMC Genet. 2007;8:32 pubmed
    ..Studies performed in other cattle populations have proposed polymorphisms in two different genes (ABCG2 and OPN) as the underlying functional QTL nucleotide...
  6. Lindner S, Halwachs S, Wassermann L, Honscha W. Expression and subcellular localization of efflux transporter ABCG2/BCRP in important tissue barriers of lactating dairy cows, sheep and goats. J Vet Pharmacol Ther. 2013;36:562-70 pubmed publisher
    Expression of efflux transporter ABCG2/BCRP in tissues barriers has shown to be associated with altered pharmaco- and toxicokinetics of xenobiotics...
  7. Caballero J, Frenette G, D Amours O, Dufour M, Oko R, Sullivan R. ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation. Biol Reprod. 2012;86:181 pubmed publisher
    ..sulfate conjugates formed intracellularly by sulfotransferases, the ATP-binding cassette membrane transporter G2 (ABCG2) might have a role in the translocation of this compound across the plasma membrane...