Gene Symbol: top2a.L
Description: DNA topoisomerase II alpha L homeolog
Alias: top2, top2a, tp2a, DNA topoisomerase II alpha L homeolog, topoisomerase (DNA) II alpha 170kDa, topoisomerase (DNA) II alpha L homeolog
Species: common platanna

Top Publications

  1. Ryu H, Furuta M, Kirkpatrick D, Gygi S, Azuma Y. PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity. J Cell Biol. 2010;191:783-94 pubmed publisher
    ..Therefore, we propose a novel mechanism for regulation of centromeric DNA catenation during mitosis by PIASy-mediated SUMOylation of TopoII?...
  2. Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
    ..Here, we investigated the processing of topoisomerase II (Top2)-DNA adducts induced by treatment with the chemotherapeutic agent etoposide...
  3. Gaggioli V, Le Viet B, Germe T, Hyrien O. DNA topoisomerase II? controls replication origin cluster licensing and firing time in Xenopus egg extracts. Nucleic Acids Res. 2013;41:7313-31 pubmed publisher
    ..Therefore, topo II? restrains MCM2-7 loading in an ICRF-193-resistant manner during origin licensing, suggesting a model for establishing the sequential firing of origin clusters. ..
  4. Ryu H, Yoshida M, Sridharan V, Kumagai A, Dunphy W, Dasso M, et al. SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin. Cell Cycle. 2015;14:2777-84 pubmed publisher
    ..Our findings provide a novel mechanistic insight regarding how TopoIIα-CTD SUMOylation contributes to mitotic centromere activity. ..
  5. Sapetto Rebow B, McLoughlin S, O Shea L, O Leary O, Willer J, Alvarez Y, et al. Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants. BMC Dev Biol. 2011;11:71 pubmed publisher
    Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility...