Sox 2


Gene Symbol: Sox 2
Description: SRY-box 2 S homeolog
Alias: SRY-box2, Xsox-2, anop3, mcops3, sox-2, sox2, sox2.L, transcription factor Sox-2, SRY (sex determining region Y)-box 2, SRY-box 2 L homeolog, XSox2, XlSOX-2, sex-determining region Y-box 2
Species: common platanna
Products:     Sox 2

Top Publications

  1. Agathocleous M, Iordanova I, Willardsen M, Xue X, Vetter M, Harris W, et al. A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. Development. 2009;136:3289-99 pubmed publisher
    ..We previously found that Wnt signaling, acting through Sox2, promotes neural competence in the Xenopus retina by activating proneural gene expression...
  2. Archer T, Jin J, Casey E. Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis. Dev Biol. 2011;350:429-40 pubmed publisher
    Sox1, Sox2 and Sox3, the three members of the SoxB1 subgroup of transcription factors, have similar sequences, expression patterns and overexpression phenotypes...
  3. Kim Y, Shin J, Na W, Kim J, Ju B, Kim W. Regulation of XFGF8 gene expression through SRY (sex-determining region Y)-box 2 in developing Xenopus embryos. Reprod Fertil Dev. 2012;24:769-77 pubmed publisher
    ..Furthermore, Xenopus SOX2 (XSOX2) physically interacted with the SOX2-binding motif within the upstream region of the XFGF8 gene in vitro and in ..
  4. Danno H, Michiue T, Hitachi K, Yukita A, Ishiura S, Asashima M. Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression. Proc Natl Acad Sci U S A. 2008;105:5408-13 pubmed publisher
    The neural-related genes Sox2, Pax6, Otx2, and Rax have been associated with severe ocular malformations such as anophthalmia and microphthalmia, but it remains unclear as to how these genes are linked functionally...
  5. Perry K, Thomas A, Henry J. Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells. Dev Biol. 2013;374:281-94 pubmed publisher
    ..We show further that numerous pluripotency genes are expressed by cells in the cornea epithelium, including: sox2, p63, various oct4 homologs, c-myc, klf4 and many others...
  6. Muñoz R, Edwards Faret G, Moreno M, Zuñiga N, Cline H, Larraín J. Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells. Dev Biol. 2015;408:229-43 pubmed publisher
    ..We studied the response of Sox2(/)3 expressing cells to spinal cord injury and their function in the regenerative process...
  7. Gaete M, Mu oz R, S nchez N, Tampe R, Moreno M, Contreras E, et al. Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cells. Neural Dev. 2012;7:13 pubmed publisher
    ..Here, we report that tail amputation results in a global increase of Sox2 levels and proliferation of Sox2(+) cells...
  8. Mizuseki K, Kishi M, Matsui M, Nakanishi S, Sasai Y. Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. Development. 1998;125:579-87 pubmed
  9. Rogers C, Harafuji N, Archer T, Cunningham D, Casey E. Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives. Mech Dev. 2009;126:42-55 pubmed publisher
    ..studies, we analyzed Sox3 function in detail in Xenopus early neural development and compared it to that of Sox2. Through these studies we identified the first targets of a SoxB1 protein during primary neurogenesis...

More Information


  1. De Robertis E, Kim S, Leyns L, Piccolo S, Bachiller D, Agius E, et al. Patterning by genes expressed in Spemann's organizer. Cold Spring Harb Symp Quant Biol. 1997;62:169-75 pubmed