Gene Symbol: rbbp8.L
Description: retinoblastoma binding protein 8 L homeolog
Alias: CtIP, rbbp8, DNA endonuclease RBBP8, CtBP-interacting protein
Species: common platanna
You Z, Shi L, Zhu Q, Wu P, Zhang Y, Basilio A, et al
. CtIP links DNA double-strand break sensing to resection. Mol Cell. 2009;36:954-69 pubmed publisher
..Using Xenopus egg extracts and human cells, we show that the tumor suppressor protein CtIP plays a critical role in this transition...
Peterson S, Li Y, Chait B, Gottesman M, Baer R, Gautier J. Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J Cell Biol. 2011;194:705-20 pubmed publisher
..In contrast to the events in S phase, M-phase resection is solely dependent on MRN-CtIP. Despite generation of RPA-ssDNA, M-phase resection does not lead to ATR activation or Rad51 chromatin association...
Peterson S, Li Y, Wu Baer F, Chait B, Baer R, Yan H, et al
. Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol Cell. 2013;49:657-67 pubmed publisher
..Here, we show that CtIP undergoes ATR-dependent hyperphosphorylation in response to DSBs...
Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
..biochemical analysis in Xenopus laevis egg extracts, we establish that the MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ..