rad51.L

Summary

Gene Symbol: rad51.L
Description: RAD51 recombinase L homeolog
Alias: brcc5, rad51, rad51-a, rad51-b, rad51a, reca, xrad51, DNA repair protein RAD51 homolog A, RAD51 homolog (RecA homolog), XRad51.1
Species: common platanna
Products:     rad51.L

Top Publications

  1. Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V. Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol. 2010;17:1305-11 pubmed publisher
    The role of Rad51 in an unperturbed cell cycle has been difficult to distinguish from its DNA repair function...
  2. Maeshima K, Morimatsu K, Shinohara A, Horii T. RAD51 homologues in Xenopus laevis: two distinct genes are highly expressed in ovary and testis. Gene. 1995;160:195-200 pubmed
    ..Two distinct Xenopus laevis RAD51 cDNA clones (XRAD51.1 and XRAD51.2) were isolated from an oocyte cDNA library using the human RAD51 cDNA (HsRAD51) as a probe...
  3. Peterson S, Li Y, Chait B, Gottesman M, Baer R, Gautier J. Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J Cell Biol. 2011;194:705-20 pubmed publisher
    ..RPA-ssDNA activates the ATR-dependent checkpoint and homology-directed repair (HDR) via Rad51-dependent mechanisms. On the other hand, the fate of DSBs sustained during vertebrate M phase is largely unknown...
  4. Hashimoto Y, Puddu F, Costanzo V. RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol. 2011;19:17-24 pubmed publisher
    ..replisome is restored by the reloading of GINS and polymerase ? onto DNA in a fashion that is dependent on RAD51 and MRE11 but independent of replication origin assembly and firing...
  5. Kolinjivadi A, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, T├ęcher H, et al. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Mol Cell. 2017;67:867-881.e7 pubmed publisher
    ..protein prevents single-stranded DNA gap accumulation at replication fork junctions and behind them by promoting Rad51 binding to replicating DNA...