Gene Symbol: rad50.L
Description: RAD50 homolog, double strand break repair protein L homeolog
Alias: rad50, RAD50 homolog, double strand break repair protein L homeolog
Species: common platanna

Top Publications

  1. Duursma A, Driscoll R, Elias J, Cimprich K. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol Cell. 2013;50:116-22 pubmed publisher
    The MRN (MRE11-RAD50-NBS1) complex has been implicated in many aspects of the DNA damage response. It has key roles in sensing and processing DNA double-strand breaks, as well as in activation of ATM (ataxia telangiectasia mutated)...
  2. Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell. 2009;20:2351-60 pubmed publisher
    ..We show that TopBP1 also interacts with the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint-regulated manner...
  3. Taylor E, Cecillon S, Bonis A, Chapman J, Povirk L, Lindsay H. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. Nucleic Acids Res. 2010;38:441-54 pubmed publisher
    ..has been demonstrated to play a role in both classical NHEJ and MMEJ, but the involvement of the analogous MRE11/RAD50/NBS1 (MRN) complex in end joining in higher eukaryotes is less certain...
  4. Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
    ..Through biochemical analysis in Xenopus laevis egg extracts, we establish that the MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent ..
  5. Di Virgilio M, Ying C, Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst). 2009;8:1311-20 pubmed publisher
    ..we show that phosphorylation of Mre11 at SQ/TQ motifs by PIKKs (PI3 Kinase-related Kinases) induces MRN (Mre11-Rad50-Nbs1) complex dissociation from chromatin by reducing Mre11 affinity for DNA...