nbn.L

Summary

Gene Symbol: nbn.L
Description: nibrin L homeolog
Alias: nbn, nbs, nbs1, nibrin L homeolog, Nijmegen breakage syndrome 1
Species: common platanna

Top Publications

  1. You Z, Chahwan C, Bailis J, Hunter T, Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol. 2005;25:5363-79 pubmed
    ..ATM activation in response to DNA damage appears to be regulated by the Mre11-Rad50-Nbs1 (MRN) complex, although the exact functional relationship between the MRN complex and ATM is uncertain...
  2. Kumar S, Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle. 2012;11:1183-94 pubmed publisher
    ..In addition, Rif1 also interacts with both ATM and the Mre11-Rad50-Nbs1 (MRN) complex, which are key regulators of checkpoint responses to double-stranded DNA breaks (DSBs)...
  3. Xu C, Wu L, Cui G, Botuyan M, Chen J, Mer G. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol. 2008;381:361-72 pubmed publisher
    The Nijmegen breakage syndrome protein Nbs1 is a component of the MRN (Mre11-Rad50-Nbs1) complex, central to the DNA damage response...
  4. Di Virgilio M, Ying C, Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst). 2009;8:1311-20 pubmed publisher
    ..show that phosphorylation of Mre11 at SQ/TQ motifs by PIKKs (PI3 Kinase-related Kinases) induces MRN (Mre11-Rad50-Nbs1) complex dissociation from chromatin by reducing Mre11 affinity for DNA...
  5. Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
    ..Through biochemical analysis in Xenopus laevis egg extracts, we establish that the MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of ..
  6. Choi S, Yoo H. Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses. Biochem Biophys Res Commun. 2016;479:5-11 pubmed publisher
    TopBP1 has been identified as a direct activator of ATR and interacts with the Nbs1 subunit of the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint-regulated manner...
  7. Wawrousek K, Fortini B, Polaczek P, Chen L, Liu Q, Dunphy W, et al. Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle. 2010;9:1156-66 pubmed
    ..Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 and ATM...
  8. Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell. 2009;20:2351-60 pubmed publisher
    ..We show that TopBP1 also interacts with the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint-regulated manner...
  9. Taylor E, Cecillon S, Bonis A, Chapman J, Povirk L, Lindsay H. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. Nucleic Acids Res. 2010;38:441-54 pubmed publisher
    ..been demonstrated to play a role in both classical NHEJ and MMEJ, but the involvement of the analogous MRE11/RAD50/NBS1 (MRN) complex in end joining in higher eukaryotes is less certain...

More Information

Publications10

  1. Duursma A, Driscoll R, Elias J, Cimprich K. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol Cell. 2013;50:116-22 pubmed publisher
    The MRN (MRE11-RAD50-NBS1) complex has been implicated in many aspects of the DNA damage response. It has key roles in sensing and processing DNA double-strand breaks, as well as in activation of ATM (ataxia telangiectasia mutated)...