Gene Symbol: mre11.L
Description: MRE11 homolog, double strand break repair nuclease L homeolog
Alias: mre11, mre11-a, mre11a, mre11a.L, double-strand break repair protein MRE11, MRE11 homolog A, double strand break repair nuclease L homeolog, MRE11 homolog, double strand break repair nuclease A, MRE11 meiotic recombination 11 homolog A
Species: common platanna

Top Publications

  1. Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell. 2009;20:2351-60 pubmed publisher
    ..We show that TopBP1 also interacts with the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint-regulated manner...
  2. Hashimoto Y, Puddu F, Costanzo V. RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol. 2011;19:17-24 pubmed publisher restored by the reloading of GINS and polymerase ? onto DNA in a fashion that is dependent on RAD51 and MRE11 but independent of replication origin assembly and firing...
  3. Taylor E, Cecillon S, Bonis A, Chapman J, Povirk L, Lindsay H. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. Nucleic Acids Res. 2010;38:441-54 pubmed publisher
    ..In budding yeast, the Mre11/Rad5/Xrs2 complex has been demonstrated to play a role in both classical NHEJ and MMEJ, but the involvement of the ..
  4. Lee J, Dunphy W. The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell. 2013;24:1343-53 pubmed publisher
    ..We have observed that egg extracts lacking the Mre11-Rad50-Nbs1 (MRN) complex show greatly, although not completely, reduced activation of Chk1 in response to ..
  5. Duursma A, Driscoll R, Elias J, Cimprich K. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol Cell. 2013;50:116-22 pubmed publisher
    The MRN (MRE11-RAD50-NBS1) complex has been implicated in many aspects of the DNA damage response. It has key roles in sensing and processing DNA double-strand breaks, as well as in activation of ATM (ataxia telangiectasia mutated)...
  6. Chen C, Zhang L, Huang N, Huang B, Kornbluth S. Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. Proc Natl Acad Sci U S A. 2013;110:20605-10 pubmed publisher
    ..Following DNA damage, ATM is activated and recruited by the MRN protein complex [meiotic recombination 11 (Mre11)/DNA repair protein Rad50/Nijmegen breakage syndrome 1 proteins] to sites of DNA damage where ATM phosphorylates ..
  7. Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
    ..Through biochemical analysis in Xenopus laevis egg extracts, we establish that the MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the ..
  8. Kolinjivadi A, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, T├ęcher H, et al. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Mol Cell. 2017;67:867-881.e7 pubmed publisher
    Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms underlying this process, we isolated Xenopus laevis Brca2...
  9. Costanzo V, Paull T, Gottesman M, Gautier J. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol. 2004;2:E110 pubmed
    b>Mre11/Rad50/Nbs1 complex (MRN) is essential to suppress the generation of double-strand breaks (DSBs) during DNA replication. MRN also plays a role in the response to DSBs created by DNA damage...

More Information


  1. Liao S, Tammaro M, Yan H. The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair. Nucleic Acids Res. 2016;44:5689-701 pubmed publisher
    ..Resection is dependent on Mre11, but its nuclease activity is critical only for ends with 5' bulky adducts...