Gene Symbol: brca1.L
Description: breast cancer 1 L homeolog
Alias: brca1, breast cancer 1 L homeolog, breast and ovarian cancer susceptibility protein, breast cancer 1, early onset
Species: common platanna

Top Publications

  1. Joukov V, Chen J, Fox E, Green J, Livingston D. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A. 2001;98:12078-83 pubmed
    The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in its own right...
  2. Long D, Joukov V, Budzowska M, Walter J. BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork. Mol Cell. 2014;56:174-85 pubmed publisher
    The tumor suppressor protein BRCA1 promotes homologous recombination (HR), a high-fidelity mechanism to repair DNA double-strand breaks (DSBs) that arise during normal replication and in response to DNA-damaging agents...
  3. Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
    ..analysis in Xenopus laevis egg extracts, we establish that the MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ends...

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