atr.L

Summary

Gene Symbol: atr.L
Description: ATR serine/threonine kinase L homeolog
Alias: XATR, atr, frp1, mec1, sckl, sckl1, serine/threonine-protein kinase atr, ataxia telangiectasia and Rad3 related, ataxia telangiectasia and Rad3-related protein, checkpoint kinase, protein kinase
Species: common platanna

Top Publications

  1. Hekmat Nejad M, You Z, Yee M, Newport J, Cimprich K. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr Biol. 2000;10:1565-73 pubmed
    ..We have cloned the Xenopus laevis homolog of ATR (XATR) and studied the function of the protein in Xenopus egg extracts...
  2. Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, et al. An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism. EMBO J. 2017;36:1182-1198 pubmed publisher
    ..show, in live cells, that Ddx19 transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR/Chk1-dependent manner, and that Ddx19 nuclear relocalization is required to clear R-loops...
  3. Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa Saito M, Kiyono T, et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci. 2010;123:225-35 pubmed publisher
    ..We report here that human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk...
  4. Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin M. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem. 2009;284:25560-8 pubmed publisher
    ..of FANCM is regulated by two mayor players in the DNA damage response: the cell cycle checkpoint kinases ATR and ATM...
  5. Yoo H, Shevchenko A, Shevchenko A, Dunphy W. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem. 2004;279:53353-64 pubmed
    In vertebrates, ATM and ATR are critical regulators of checkpoint responses to damaged and incompletely replicated DNA...
  6. Petersen P, Chou D, You Z, Hunter T, Walter J, Walter G. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol. 2006;26:1997-2011 pubmed
    ..Evidence was provided that PP2A counteracts an inhibitory protein kinase that phosphorylates and inactivates a crucial Cdc45 loading factor...
  7. Kumagai A, Lee J, Yoo H, Dunphy W. TopBP1 activates the ATR-ATRIP complex. Cell. 2006;124:943-55 pubmed
    b>ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control of its kinase activity are unknown...
  8. Trenz K, Smith E, Smith S, Costanzo V. ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J. 2006;25:1764-74 pubmed
    Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia Rad3-related (ATR) and the Mre11/Rad50/Nbs1 complex ensure genome stability in response to DNA damage. However, their essential role in DNA metabolism remains unknown...
  9. Lee J, Kumagai A, Dunphy W. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem. 2007;282:28036-44 pubmed
    TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA...

More Information

Publications18

  1. Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem. 2007;282:17501-6 pubmed
    ATM (ataxia-telangiectasia mutated) is necessary for activation of Chk1 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replication stress...
  2. Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, et al. An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol. 2009;11:278-85 pubmed publisher
    Activation of the protein kinases ATM and ATR following chromosomal breakage prevents initiation of DNA replication and entry into mitosis...
  3. Kim S, Kumagai A, Lee J, Dunphy W. Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. J Biol Chem. 2005;280:38355-64 pubmed
    b>ATR, a critical regulator of DNA replication and damage checkpoint responses, possesses a binding partner called ATRIP...
  4. Peterson S, Li Y, Wu Baer F, Chait B, Baer R, Yan H, et al. Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol Cell. 2013;49:657-67 pubmed publisher
    ..ATM and ATR kinases are activated sequentially...
  5. Destephanis D, McLeod M, Yan S. REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts. Biochem Biophys Res Commun. 2015;460:609-15 pubmed publisher
    ..we provide evidence to demonstrate that REV1 plays a previously unidentified but important role in the ATR-Chk1 checkpoint activation in response to mitomycin C (MMC)-induced ICLs in Xenopus egg extracts...
  6. Guo Z, Kumagai A, Wang S, Dunphy W. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev. 2000;14:2745-56 pubmed
    The checkpoint kinase Xchk1 becomes phosphorylated in Xenopus egg extracts in response to DNA replication blocks or UV-damaged DNA. Xchk1 is also required for the cell cycle delay that is induced by unreplicated or UV-damaged DNA...
  7. Duursma A, Driscoll R, Elias J, Cimprich K. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol Cell. 2013;50:116-22 pubmed publisher
    ..We reveal a function for MRN in ATR (ATM- and RAD3-related) activation by using defined ATR-activating DNA structures in Xenopus egg extracts...
  8. Willis J, Patel Y, Lentz B, Yan S. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proc Natl Acad Sci U S A. 2013;110:10592-7 pubmed publisher
    ..Here, we provide evidence showing that hydrogen peroxide (H2O2) triggers checkpoint kinase 1 (Chk1) phosphorylation in an ATR [ataxia-telangiectasia mutated (ATM) and Rad3-related]-dependent but ATM-..
  9. Hashimoto Y, Tsujimura T, Sugino A, Takisawa H. The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes Cells. 2006;11:993-1007 pubmed
    b>ATR-dependent activation of the kinase Chk1 is the initial step in signal transduction in the DNA replication checkpoint, which allows a cell to enter mitosis only after the completion of DNA replication...