pCPF5603_44

Summary

Gene Symbol: pCPF5603_44
Description: beta-2 toxin
Species: clostridium perfringens

Publications

  1. Atypical cpb2 genes, encoding beta2-toxin in Clostridium perfringens isolates of nonporcine origin
    B Helen Jost
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell St, Tucson, AZ 85721, USA
    Infect Immun 73:652-6
  2. Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene
    Derek J Fisher
    Department of Molecular Genetics and Biochemistry, Molecular Virology and Microbiology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Microbiol 56:747-62
  3. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model
    Sameera Sayeed
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Microbiol 67:15-30

Scientific Experts

  • B H Jost
  • Derek J Fisher
  • Sameera Sayeed
  • Bruce A McClane
  • Yue Chen
  • Phalguni Gupta
  • Francisco A Uzal
  • Jorge E Vidal
  • Julian I Rood
  • Juliann Saputo
  • Kazuaki Miyamoto
  • Mahfuzur R Sarker
  • Benjamin Harrison
  • Shigero Akimoto

Detail Information

Publications3

  1. Atypical cpb2 genes, encoding beta2-toxin in Clostridium perfringens isolates of nonporcine origin
    B Helen Jost
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell St, Tucson, AZ 85721, USA
    Infect Immun 73:652-6
    ..However, the identification of apparently nonexpressed, atypical cpb2 genes raises the question of whether this protein plays the same role in enteritis in other animal species...
  2. Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene
    Derek J Fisher
    Department of Molecular Genetics and Biochemistry, Molecular Virology and Microbiology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Microbiol 56:747-62
    ..CPB2h1 is approximately 10-fold more cytotoxic for CaCo-2 cells than is CPB2h2. Collectively, these results suggest that CPB2 could be an accessory toxin in C. perfringens enterotoxin (CPE)-associated AAD/SD...
  3. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model
    Sameera Sayeed
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Microbiol 67:15-30
    ..These results indicate that CPB is both required and sufficient for CN3685-induced enteric pathology, supporting a key role for this toxin in type C intestinal pathogenesis...