CLB4

Summary

Gene Symbol: CLB4
Description: Clb4p
Species:

Top Publications

  1. ncbi Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae
    I Fitch
    Cold Spring Harbor Laboratory, New York 11724
    Mol Biol Cell 3:805-18. 1992
  2. ncbi The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae
    U Surana
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 65:145-61. 1991
  3. ncbi Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2
    H Richardson
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Genes Dev 6:2021-34. 1992
  4. ncbi Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase
    Yao Wei Tzeng
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Fungal Genet Biol 48:966-78. 2011
  5. ncbi Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae
    M Angeles Juanes
    Department of Genetics, University of Cambridge, Cambridge, UK
    Cell Cycle 10:1988-97. 2011
  6. ncbi Ubiquitylation regulates interactions of astral microtubules with the cleavage apparatus
    Daniel Kammerer
    Heidelberg University Biochemistry Center BZH, Heidelberg, Germany
    Curr Biol 20:1233-43. 2010
  7. ncbi Dissection of mitotic functions of the yeast cyclin Clb2
    Tanja Kuczera
    Institute of Microbiology and Genetics, Georg August University, Gottingen, Germany
    Cell Cycle 9:2611-9. 2010
  8. ncbi Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiae
    Amy E Ikui
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Genetics 183:51-61. 2009
  9. ncbi Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae
    Brendan M Kiburz
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 19:1199-209. 2008
  10. ncbi The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p
    Jeffrey K Moore
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Mol Biol Cell 17:178-91. 2006

Scientific Experts

  • Amy E Ikui
  • Matteo Barberis
  • Yao Wei Tzeng
  • M Angeles Juanes
  • Tanja Kuczera
  • Daniel Kammerer
  • Brendan M Kiburz
  • Jeffrey K Moore
  • Karen Crasta
  • Hiromi Maekawa
  • Eric Bailly
  • Christian Linke
  • Francesc Posas
  • Hans Lehrach
  • Edda Klipp
  • Miquel À Adrover
  • Alberto Gonzalez-Novo
  • F M Yeong
  • Sylvia Krobitsch
  • Marisa Segal
  • Rogier ten Hoopen
  • Scott C Schuyler
  • Chun Hao Wu
  • Yue Li Juang
  • JAMES N HUANG
  • Lea Stevermann
  • Dimitris Liakopoulos
  • Stefan Irniger
  • Özgür Bayram
  • M Segal
  • Fatih Sari
  • Gerhard H Braus
  • Angelika Amon
  • A Sreenivasan
  • Adele L Marston
  • Uttam Surana
  • Mark Winey
  • Garry Morgan
  • Rita K Miller
  • Phillips Huang
  • Sonia D'Silva
  • S I Reed
  • U Surana
  • Elmar Schiebel
  • Marie-Noelle Simon
  • Sandrine Cabantous
  • Alain Bernadac
  • Marie Noelle Simon
  • Delphine Sondaz
  • H H Lim
  • Y Wang
  • E D Salmon
  • P Maddox
  • K Bloom
  • D J Clarke
  • D Kellogg
  • N Grandin
  • I Fitch
  • H Richardson
  • K Nasmyth
  • C Dahmann
  • A Amon
  • D J Lew
  • B Futcher
  • B Byers
  • L Goetsch
  • K Sugimoto
  • M Henze
  • T Schuster
  • A B Futcher
  • C Price
  • H Robitsch

Detail Information

Publications18

  1. ncbi Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae
    I Fitch
    Cold Spring Harbor Laboratory, New York 11724
    Mol Biol Cell 3:805-18. 1992
    ..Here we present the sequences of another related pair of B-type cyclin genes, which we term CLB3 and CLB4. Although CLB1 and CLB2 mRNAs rise in abundance at the time of nuclear division, CLB3 and CLB4 are turned on ..
  2. ncbi The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae
    U Surana
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 65:145-61. 1991
    ..Three of these (CLB1, CLB2, and CLB4) encode proteins strongly homologous to G2-specific B-type cyclins...
  3. ncbi Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2
    H Richardson
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Genes Dev 6:2021-34. 1992
    We have cloned four cyclin-B homologs from Saccharomyces cerevisiae, CLB1-CLB4, using the polymerase chain reaction and low stringency hybridization approaches...
  4. ncbi Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase
    Yao Wei Tzeng
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Fungal Genet Biol 48:966-78. 2011
    ....
  5. ncbi Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae
    M Angeles Juanes
    Department of Genetics, University of Cambridge, Cambridge, UK
    Cell Cycle 10:1988-97. 2011
    ..By contrast, clb3? clb4? cells delayed spindle assembly downstream to Ase1p recruitment...
  6. ncbi Ubiquitylation regulates interactions of astral microtubules with the cleavage apparatus
    Daniel Kammerer
    Heidelberg University Biochemistry Center BZH, Heidelberg, Germany
    Curr Biol 20:1233-43. 2010
    ..In budding yeast, the Adenomatous Polyposis Coli-related protein Kar9, yeast EB1, and Myo2, a type V myosin, mediate positioning of the mitotic spindle close to the septin-anchored cleavage apparatus at the bud neck...
  7. ncbi Dissection of mitotic functions of the yeast cyclin Clb2
    Tanja Kuczera
    Institute of Microbiology and Genetics, Georg August University, Gottingen, Germany
    Cell Cycle 9:2611-9. 2010
    ..among the four mitotic cyclins, Clb1-4, manifested by data showing that simultaneous deletion of the CLB1, CLB3 and CLB4 genes has only minor effects on mitosis...
  8. ncbi Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiae
    Amy E Ikui
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Genetics 183:51-61. 2009
    ..In the absence of the related CLB3 and CLB4 cyclins, the spindle integrity checkpoint becomes essential, since bub3 or mad2 deletion is lethal in a clb3 clb4 ..
  9. ncbi Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae
    Brendan M Kiburz
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 19:1199-209. 2008
    ..In contrast, Sgo1 is important to bias sister kinetochores toward biorientation. We suggest that Sgo1 acts at sister kinetochores to promote their biorientation...
  10. ncbi The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p
    Jeffrey K Moore
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Mol Biol Cell 17:178-91. 2006
    ..These findings provide further insight into a mechanism for directing centrosomal inheritance...
  11. ncbi Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex
    Hiromi Maekawa
    The Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Genes Dev 18:1709-24. 2004
    ..It has been suggested that cyclin-dependent kinase Cdc28, in complex with cyclin Clb4, associates only with the SPB in the mother cell and so prevents Kar9 binding to this SPB...
  12. ncbi Differential cellular localization among mitotic cyclins from Saccharomyces cerevisiae: a new role for the axial budding protein Bud3 in targeting Clb2 to the mother-bud neck
    Eric Bailly
    Laboratoire d Ingenierie des Systemes Macromoleculaires CNRS UPR9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Cell Sci 116:4119-30. 2003
    ..M-phase in budding yeast, despite its functional redundancy with three closely related cyclins Clb1, Clb3 and Clb4. Here, we further investigate the mechanisms controlling the cellular distribution of Clb2 in living cells...
  13. ncbi Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase
    F M Yeong
    Institute of Molecular and Cell Biology, Singapore 117609, Singapore
    Mol Cell Biol 21:5071-81. 2001
    ..anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate APC(Hct1) to allow Clb2 accumulation...
  14. ncbi Coordinated spindle assembly and orientation requires Clb5p-dependent kinase in budding yeast
    M Segal
    Department of Molecular Biology, MB7, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 148:441-52. 2000
    ..In contrast, B-type cyclins, Clb3p and Clb4p, though partially redundant with Clb5p for an early role in spindle morphogenesis, preferentially promote spindle assembly...
  15. ncbi The elm1 kinase functions in a mitotic signaling network in budding yeast
    A Sreenivasan
    Sinsheimer Laboratories, Department of Biology, University of California, Santa Cruz, California 95064, USA
    Mol Cell Biol 19:7983-94. 1999
    ....
  16. ncbi Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis
    N Grandin
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Mol Cell Biol 13:2113-25. 1993
    We have studied the patterns of expression of four B-type cyclins (Clbs), Clb1, Clb2, Clb3, and Clb4, and their ability to activate p34cdc28 during the mitotic and meiotic cell cycles of Saccharomyces cerevisiae...
  17. ncbi Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins
    Matteo Barberis
    Institute for Biology, Theoretical Biophysics, Humboldt University Berlin, Berlin, Germany
    Biotechnol Adv 30:108-30. 2012
    ..Our results highlight an additional role for Sic1 in regulating Cdk1-Clb complexes, coordinating their appearance...
  18. ncbi Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins
    Karen Crasta
    Institute of Molecular and Cell Biology, Proteos, Singapore
    EMBO J 25:2551-63. 2006
    ....