Gene Symbol: ompA
Description: major outer membrane porin
Species: Chlamydia trachomatis D/UW-3/CX
Products:     ompA

Top Publications

  1. Stephens R, Sanchez Pescador R, Wagar E, Inouye C, Urdea M. Diversity of Chlamydia trachomatis major outer membrane protein genes. J Bacteriol. 1987;169:3879-85 pubmed
    ..The molecular basis of omp1 gene diversity among C. trachomatis serovars was observed to be clustered nucleotide substitutions for closely related serovars and insertions or deletions for distantly related serovars...
  2. Dean D, Millman K. Molecular and mutation trends analyses of omp1 alleles for serovar E of Chlamydia trachomatis. Implications for the immunopathogenesis of disease. J Clin Invest. 1997;99:475-83 pubmed publisher
    ..Understanding the mutation trends, phylogeny, and molecular epidemiology of E variants is essential for designing public health control interventions and a vaccine...
  3. Hayes L, Pickett M, Conlan J, Ferris S, Everson J, Ward M, et al. The major outer-membrane proteins of Chlamydia trachomatis serovars A and B: intra-serovar amino acid changes do not alter specificities of serovar- and C subspecies-reactive antibody-binding domains. J Gen Microbiol. 1990;136:1559-66 pubmed publisher
    ..Within a given serovar, however, limited interchange of functionally related amino acids may occur without impairing the binding of serovar-specific antibody...
  4. Stothard D, Boguslawski G, Jones R. Phylogenetic analysis of the Chlamydia trachomatis major outer membrane protein and examination of potential pathogenic determinants. Infect Immun. 1998;66:3618-25 pubmed
    ..Therefore, the role of MOMP in disease pathogenesis and infection may be passive, and it may not be the major ligand responsible for directing infection of various human cell types...
  5. Sayada C, Vretou E, Orfila J, Elion J, Denamur E. Heterogeneity within the first constant segment of the major outer membrane protein gene in Chlamydia trachomatis serovar D/Da distinguishes 2 lineages. C R Acad Sci III. 1995;318:943-9 pubmed
    ..The observed ompl genetic diversity of serovar D/Da strains in regions involved in T- and B-cell responses might add another level of complexity to the design of a subunit vaccine. ..
  6. Stephens R, Mullenbach G, Sanchez Pescador R, Agabian N. Sequence analysis of the major outer membrane protein gene from Chlamydia trachomatis serovar L2. J Bacteriol. 1986;168:1277-82 pubmed
    ..The primary structure of MOMP determined from the translated DNA sequence demonstrated nine cysteine residues and a remarkably homogeneous distribution of charged and hydrophobic residues. ..
  7. Pannekoek Y, Westenberg S, De Vries J, Repping S, Spanjaard L, Eijk P, et al. PCR assessment of Chlamydia trachomatis infection of semen specimens processed for artificial insemination. J Clin Microbiol. 2000;38:3763-7 pubmed
    ..trachomatis-infected ejaculates already stored and will thus improve the microbiological quality of AID, since discrepancies in the presence of C. trachomatis in urine and semen specimens have been reported. ..
  8. Sayada C, Denamur E, Elion J. Complete sequence of the major outer membrane protein-encoding gene of Chlamydia trachomatis serovar Da. Gene. 1992;120:129-30 pubmed
    ..These regions contain the B-cell epitopes. Additional differences were found in the constant domains I and II, thought to participate in the T-cell response. ..
  9. Peterson E, Markoff B, de la Maza L. The major outer membrane protein nucleotide sequence of Chlamydia trachomatis, serovar E. Nucleic Acids Res. 1990;18:3414 pubmed

More Information


  1. Lister N, Tabrizi S, Fairley C, Smith A, Janssen P, Garland S. Variability of the Chlamydia trachomatis omp1 gene detected in samples from men tested in male-only saunas in Melbourne, Australia. J Clin Microbiol. 2004;42:2596-601 pubmed publisher
    ..trachomatis elsewhere. No significant genetic variants were found, as most variable positions were silent and were detected only in single samples...
  2. Stephens R, Wagar E, Edman U. Developmental regulation of tandem promoters for the major outer membrane protein gene of Chlamydia trachomatis. J Bacteriol. 1988;170:744-50 pubmed
    ..Mapping of the initiating nucleotide for each transcript suggested that this gene is regulated by differential transcription from tandem promoters...
  3. Halse T, Musser K, Limberger R. A multiplexed real-time PCR assay for rapid detection of Chlamydia trachomatis and identification of serovar L-2, the major cause of Lymphogranuloma venereum in New York. Mol Cell Probes. 2006;20:290-7 pubmed publisher
    ..This assay represents the first real-time PCR method capable of detecting C. trachomatis DNA, and of simultaneously identifying C. trachomatis infection as serovar L-2...
  4. Stothard D, Van Der Pol B, Smith N, Jones R. Effect of serial passage in tissue culture on sequence of omp1 from Chlamydia trachomatis clinical isolates. J Clin Microbiol. 1998;36:3686-8 pubmed
    ..The possibility that C. trachomatis omp1 might undergo mutation during such expansion has not been examined systematically. We found no differences in the omp1 sequences from 10 clinical specimens before and after 20 in vitro passages...
  5. Hsu M, Tsai P, Chen K, Li L, Chiang C, Tsai J, et al. Genotyping of Chlamydia trachomatis from clinical specimens in Taiwan. J Med Microbiol. 2006;55:301-8 pubmed publisher
    ..018) between northern and southern Taiwan. Sequence mutation analysis by blast searching against GenBank reference sequences identified 12 genetic variants from a total of 102 omp1 gene sequences...