ERVW-1

Summary

Gene Symbol: ERVW-1
Description: endogenous retrovirus group W member 1, envelope
Alias: env, syncytin-1, ERV-W1 provirus ancestral Env polyprotein, ERVWE1 envelope protein, endogenous retrovirus group W member 1, envelope glycoprotein, envelope polyprotein
Species: chimpanzee

Top Publications

  1. Mallet F, Bouton O, Prudhomme S, Cheynet V, Oriol G, Bonnaud B, et al. The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology. Proc Natl Acad Sci U S A. 2004;101:1731-6 pubmed publisher
    ..is the case for the ERVWE1 locus of the human endogenous retrovirus W family (HERV-W), which encodes an envelope glycoprotein (syncytin) likely involved in trophoblast differentiation...
  2. Bonnaud B, Bouton O, Oriol G, Cheynet V, Duret L, Mallet F. Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. Mol Biol Evol. 2004;21:1895-901 pubmed publisher
    ..This Env protein (syncytin) is a highly fusogenic membrane glycoprotein and has been proposed to be involved in hominoid ..
  3. Cáceres M, Thomas J. The gene of retroviral origin Syncytin 1 is specific to hominoids and is inactive in Old World monkeys. J Hered. 2006;97:100-6 pubmed
    b>Syncytin 1 is one of the best known examples of recent acquisition of a new gene from an endogenous retrovirus (HERV) in the human genome and has been implicated in placental physiology...