Gene Symbol: APOE
Description: apolipoprotein E
Alias: apolipoprotein E, apo-E
Hanlon C, Rubinsztein D. Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans. Atherosclerosis. 1995;112:85-90 pubmed
b>Apolipoprotein E is a secretory glycoprotein that associates with lipoprotein particles and is coded for by a single locus on chromosome 19...
Fullerton S, Clark A, Weiss K, Nickerson D, Taylor S, Stengard J, et al
. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet. 2000;67:881-900 pubmed
Three common protein isoforms of apolipoprotein E (apoE), encoded by the epsilon2, epsilon3, and epsilon4 alleles of the APOE gene, differ in their association with cardiovascular and Alzheimer's disease risk...
Finch C, Stanford C. Meat-adaptive genes and the evolution of slower aging in humans. Q Rev Biol. 2004;79:3-50 pubmed
..One candidate gene is apolipoprotein E (apoE), with the E3 allele evolved in the genus Homo that reduces the risks for Alzheimer's and vascular ..
Gearing M, Rebeck G, Hyman B, Tigges J, Mirra S. Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease. Proc Natl Acad Sci U S A. 1994;91:9382-6 pubmed
..Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in human aging and Alzheimer disease...
Nickerson D, Taylor S, Fullerton S, Weiss K, Clark A, Steng rd J, et al
. Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. Genome Res. 2000;10:1532-45 pubmed
..We present results from a systematic investigation of variation at the human apolipoprotein E locus (APOE), as well as the evaluation of the two-tiered sampling strategy based on these data...
Kasap M, Sazci A, Akpinar G, Ergul E. Apolipoprotein E phylogeny and evolution. Cell Biochem Funct. 2008;26:43-50 pubmed
Among apolipoproteins, apolipoprotein E (Apo E) plays a pivotal role in lipid transport and is proposed to be involved in neural repair. Because of a long divergence history of apolipoproteins, it is unclear how Apo E evolved in time...
McIntosh A, Bennett C, Dickson D, Anestis S, Watts D, Webster T, et al
. The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes). PLoS ONE. 2012;7:e47760 pubmed publisher
The human apolipoprotein E (APOE) gene is polymorphic, with three primary alleles (E2, E3, E4) that differ at two key non-synonymous sites...