Gene Symbol: TCF3
Description: transcription factor 3
Alias: G12, transcription factor E2-alpha, class A basic helix-loop-helix transcription factor G12, helix-loop-helix protein E12, helix-loop-helix protein E47, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
Suda K, Nornes H, Neuman T. Class A basic helix-loop-helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy. Neurosci Lett. 1994;177:87-90 pubmed
..Blocking the expression of individual class A bHLH transcription factors has no detectable effect. These results demonstrate that class A bHLH transcription factors have a functional redundancy during neuronal development. ..
Dechesne C, Wei Q, Eldridge J, Gannoun Zaki L, Millasseau P, Bougueleret L, et al
. E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol Cell Biol. 1994;14:5474-86 pubmed
Conlon T, Meyer K. Cloning and functional characterisation of avian transcription factor E2A. BMC Immunol. 2004;5:11 pubmed
Schoetz U, Cervelli M, Wang Y, Fiedler P, Buerstedde J. E2A expression stimulates Ig hypermutation. J Immunol. 2006;177:395-400 pubmed
..The defect is complemented by the expression of cDNAs corresponding to either of the two E2A splice variants E12 or E47. The results suggest that E2A-encoded proteins enhance Ig hypermutation by recruitment of AID to the Ig loci. ..
Kitao H, Kimura M, Yamamoto K, Seo H, Namikoshi K, Agata Y, et al
. Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion. Int Immunol. 2008;20:277-84 pubmed publisher
..Thus, E2A may contribute to GCV by maintaining histone acetylation, which could be a prerequisite for targeting or full deaminase function of AID. ..
Yabuki M, Ordinario E, Cummings W, Fujii M, Maizels N. E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol. 2009;182:408-15 pubmed
..Thus, E2A acts in cis to promote Ig gene diversification, and G(1) phase is the critical window for E2A action. ..
Toyonaga K, Kikuchi H, Yamashita K, Nakayama M, Chijiiwa K, Nakayama T. E2A participates in a fine control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes. FEBS J. 2009;276:1418-28 pubmed publisher
..These findings will contribute to the resolution of molecular mechanisms of negative selection of B cells and also auto-immune diseases. ..
Yang H, Silva A, Koyano Nakagawa N, McLoon S. Progenitor cell maturation in the developing vertebrate retina. Dev Dyn. 2009;238:2823-36 pubmed publisher
..Our results show that the preneurogenic-to-neurogenic transition is a highly organized unidirectional step made in unison by neighboring cells. ..