Gene Symbol: SREBF1
Description: sterol regulatory element binding transcription factor 1
Alias: SREBP-1, SREBP1, sterol regulatory element-binding protein 1, sterol regulatory element binding protein 1
Species: chicken
Products:     SREBF1

Top Publications

  1. Yin L, Zhang Y, Hillgartner F. Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes. J Biol Chem. 2002;277:19554-65 pubmed
    ..Here, we also show that alterations in SREBP expression play a role in mediating cell type-dependent differences in T3 regulation of ACCalpha transcription. ..
  2. Assaf S, Lagarrigue S, Daval S, Sansom M, Leclercq B, Michel J, et al. Genetic linkage and expression analysis of SREBP and lipogenic genes in fat and lean chicken. Comp Biochem Physiol B Biochem Mol Biol. 2004;137:433-41 pubmed
    ..These results emphasised the interest to perform expression and genetic linkage studies jointly, to progress in identifying the genetic origin of variability of a quantitative trait. ..
  3. Seol H, Sato K, Matsubara Y, Schneider W, Akiba Y. Modulation of sterol regulatory element binding protein-2 in response to rapid follicle development in chickens. Comp Biochem Physiol B Biochem Mol Biol. 2007;147:698-703 pubmed
    ..These results suggest that SREBP-2, which might be regulated by LXRalpha, is involved in the rapid growth stages of follicle development in avian species. ..
  4. Park H, Zhang Y, DU C, Welzig C, Madias C, Aronovitz M, et al. Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice. Circ Res. 2009;105:287-94 pubmed publisher
  5. Wang L, Na W, Wang Y, Wang Y, Wang N, Li Y, et al. [Chicken SREBP1 gene antiserums preparation and its tissue expression characterization]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010;26:1241-5 pubmed
    The aim of this study was to prepare the antiserums against chicken sterol regulatory element binding protein1 (SREBP1), and to analyze the expression of SREBP1 in chicken tissues...
  6. Fu R, Liu R, Zhao G, Zheng M, Chen J, Wen J. Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens. Gene. 2014;537:120-5 pubmed publisher
    ..Taken together, all five transcription factors studied play roles in lipid metabolism in chickens with C/EBP? and PPAR? being important effectors. ..
  7. Li Q, Zhao X, Gilbert E, Liu Y, Wang Y, Qiu M, et al. Confined housing system increased abdominal and subcutaneous fat deposition and gene expressions of carbohydrate response element-binding protein and sterol regulatory element-binding protein 1 in chicken. Genet Mol Res. 2015;14:1220-8 pubmed publisher
    ..carbohydrate response element-binding protein (ChREBP), sterol regulatory element-binding protein-1 (SREBP1), and fatty acid synthase were detected...
  8. Gondret F, Ferr P, Dugail I. ADD-1/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species. J Lipid Res. 2001;42:106-13 pubmed
    ..Gondret, F., P. Ferré, and I. Dugail. ADD-1/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species. J. Lipid Res. 2001. 42: 106;-113...
  9. Talukdar S, Hillgartner F. The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. J Lipid Res. 2006;47:2451-61 pubmed

More Information


  1. Wang P, Ko Y, Chin H, Hsu C, Ding S, Chen C. The effect of feed restriction on expression of hepatic lipogenic genes in broiler chickens and the function of SREBP1. Comp Biochem Physiol B Biochem Mol Biol. 2009;153:327-31 pubmed publisher
    ..Second, three small interfering RNA (siRNA) oligonucleotides against SREBP1 were designed to be used in transfecting a chicken hepatocarcinoma cell line LMH...
  2. Liu S, Wang Y, Wang L, Wang N, Li Y, Li H. Transdifferentiation of fibroblasts into adipocyte-like cells by chicken adipogenic transcription factors. Comp Biochem Physiol A Mol Integr Physiol. 2010;156:502-8 pubmed publisher
    ..This suggests that C/EBPalpha, PPARgamma and SREBP-1 play a crucial role in chicken adipogenesis. ..