Gene Symbol: SP1
Description: Sp1 transcription factor
Alias: transcription factor Sp1, transcription factor
Chamboredon S, Briggs J, Vial E, Hurault J, Galvagni F, Oliviero S, et al
. v-Jun downregulates the SPARC target gene by binding to the proximal promoter indirectly through Sp1/3. Oncogene. 2003;22:4047-61 pubmed
..shift and pull-down assays in vitro, and transient transfections and chromatin immunoprecipitation assays in Sp1/3-deficient Drosophila SL2 cells and in chick embryo fibroblasts, we show that (i) Sp1 and/or Sp3 is required for ..
Chamboredon S, Castellazzi M. v-Jun downregulates the alpha 2 (I) collagen target gene indirectly through Sp1/3. Oncogene. 2005;24:2547-57 pubmed
..Extensive analysis, conducted in CEFs and in Sp1/3-deficient Drosophila SL2 cells, further showed that (i) high constitutive activity of -433/+11 requires a direct ..
Hübner K, Phi van L. Sp1 and Sp3 regulate transcription of the chicken GAS41 gene. Biochim Biophys Acta. 2010;1799:442-7 pubmed publisher
..Electrophoretic mobility shift assays and chromatin immunoprecipitation analyses revealed that Sp1 and Sp3 bind to this promoter...
H bner K, Phi van L. In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites. DNA Cell Biol. 2012;31:180-6 pubmed publisher
..reaction, we were able to map the Orc2-binding site to a region of the lysozyme GAS41 origin that contains multiple Sp1/Sp3-binding sites co-mapping with two DNase I hypersensitive sites...
Parakati R, DiMario J. Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis. J Biol Chem. 2005;280:21284-94 pubmed
..differentiation via expression of the fibroblast growth factor receptor 1 (FGFR1) gene is positively regulated by Sp1 and negatively regulated by E2F4-based transcriptional complexes...
Magee C, Nurminskaya M, Faverman L, Galera P, Linsenmayer T. SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes. J Biol Chem. 2005;280:25331-8 pubmed
..In the present study, we examined the role of SP3/SP1 transcription factors in the regulation of the Col10a1 promoter...