SOX9

Summary

Gene Symbol: SOX9
Description: SRY (sex determining region Y)-box 9
Alias: SOX-9, transcription factor SOX-9
Species: chicken
Products:     SOX9

Top Publications

  1. Nagy A, K nesi E, Rentsendorj O, Moln r A, Sz n si T, Sink I, et al. Evolutionarily conserved, growth plate zone-specific regulation of the matrilin-1 promoter: L-Sox5/Sox6 and Nfi factors bound near TATA finely tune activation by Sox9. Mol Cell Biol. 2011;31:686-99 pubmed publisher
    ..The proximal elements include a Pe1 element binding the chondrogenic L-Sox5, Sox6, and Sox9 proteins, a SI element binding Nfi proteins, and an initiator Ine element binding the Sox trio and other factors...
  2. Kent J, Wheatley S, Andrews J, Sinclair A, Koopman P. A male-specific role for SOX9 in vertebrate sex determination. Development. 1996;122:2813-22 pubmed
    ..with campomelic dysplasia, a bone dysmorphology and XY sex reversal syndrome, indicate that the SRY-related gene SOX9 is involved in both skeletal development and sex determination...
  3. Simões Costa M, Tan Cabugao J, Antoshechkin I, Sauka Spengler T, Bronner M. Transcriptome analysis reveals novel players in the cranial neural crest gene regulatory network. Genome Res. 2014;24:281-90 pubmed publisher
    ..The results suggest that ETS1 and SOX9 may act as pan-neural crest regulators of the migratory CNC...
  4. Healy C, Uwanogho D, Sharpe P. Regulation and role of Sox9 in cartilage formation. Dev Dyn. 1999;215:69-78 pubmed
    The HMG-domain transcription factor Sox9 is a known regulator of the type II collagen gene, a major developmentally regulated protein of cartilage...
  5. Montero J, Giron B, Arrechedera H, Cheng Y, Scotting P, Chimal Monroy J, et al. Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart. Mech Dev. 2002;118:199-202 pubmed
    We describe the expression pattern of Sox8, Sox9 and Sox10 during the development of the chick embryo heart. These Sox genes constitute the group E of the large Sox family of transcription factors...
  6. Moniot B, Biau S, Faure S, Nielsen C, Berta P, Roberts D, et al. SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals. Development. 2004;131:3795-804 pubmed
    ..We report herein the expression pattern of Sox9 during GI development, and provide evidence that it functions, in part, to define the pyloric sphincter epithelium...
  7. Liu J, Wu M, Yan C, Chau B, So H, Ng A, et al. Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling. Proc Natl Acad Sci U S A. 2013;110:2882-7 pubmed publisher
    ..Among these, Sry-related HMG box-9 (Sox9) and Snail2 have been implicated in both the induction of NCC identity and, together with phoshorylation, NCC ..
  8. Cairns D, Liu R, Sen M, Canner J, Schindeler A, Little D, et al. Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS ONE. 2012;7:e39642 pubmed publisher
    ..2 and Sox9 act downstream of TGFß or BMP2 to promote this cell fate transition. We found that Nkx3...
  9. Kumar D, Lassar A. The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization. Mol Cell Biol. 2009;29:4262-73 pubmed publisher
    ..Transfection of cells with agents that block actin polymerization enhance the ability of either exogenous Sox9 or a Gal4 DBD-Sox9 fusion protein to activate gene expression...

More Information

Publications22

  1. Uwanogho D, Rex M, Cartwright E, Pearl G, Healy C, Scotting P, et al. Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech Dev. 1995;49:23-36 pubmed
    ..cSox11 also exhibits a lineage restricted pattern of expression in the peripheral nervous system. ..
  2. Huang B, Brugger S, Lyons K. Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem. 2010;285:27702-12 pubmed publisher
    ..b>Sox9 and T-cell factor (TCF) x lymphoid enhancer factor (LEF) factors contain HMG domains and bind to related consensus ..
  3. Kang P, Lee H, Glasgow S, Finley M, Donti T, Gaber Z, et al. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012;74:79-94 pubmed publisher
    ..a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis...
  4. Peacock J, Levay A, Gillaspie D, Tao G, Lincoln J. Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res. 2010;106:712-9 pubmed publisher
    ..The SRY-related transcription factor Sox9 is expressed in developing and mature heart valves, and its function is required for expression of cartilage-..
  5. Juhasz T, Matta C, Somogyi C, Katona E, Takács R, Soha R, et al. Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures. Cell Signal. 2014;26:468-82 pubmed publisher
    ..through enhanced expression, phosphorylation and nuclear signals of the main chondrogenic transcription factor Sox9. Along with increased cAMP levels, a significantly enhanced protein kinase A (PKA) activity was also detected and ..
  6. Takimoto A, Oro M, Hiraki Y, Shukunami C. Direct conversion of tenocytes into chondrocytes by Sox9. Exp Cell Res. 2012;318:1492-507 pubmed publisher
    b>Sox9 is a high-mobility group box-containing transcription factor that functions as a key regulator of chondrogenesis...
  7. Moniot B, Boizet Bonhoure B, Poulat F. Male specific expression of lipocalin-type prostaglandin D synthase (cPTGDS) during chicken gonadal differentiation: relationship with cSOX9. Sex Dev. 2008;2:96-103 pubmed publisher
    As in mammals, the SOX9 gene (cSOX9) is specifically expressed in male differentiating Sertoli cells during chicken gonadal development...
  8. Zákány R, Szijgyarto Z, Matta C, Juhasz T, Csortos C, Szucs K, et al. Hydrogen peroxide inhibits formation of cartilage in chicken micromass cultures and decreases the activity of calcineurin: implication of ERK1/2 and Sox9 pathways. Exp Cell Res. 2005;305:190-9 pubmed
    ..both the amount of cartilage and the expression of mRNAs of aggrecan and the chondrogenic transcription factor Sox9. Cartilage formation was inhibited by H(2)O(2) in a concentration-dependent manner without loss of cellular ..
  9. Kamachi Y, Cheah K, Kondoh H. Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol Cell Biol. 1999;19:107-20 pubmed
    ..the mechanism of target selection by comparing SOX1/2/3, which activate delta-crystallin minimal enhancer DC5, with SOX9, which activates Col2a1 minimal enhancer COL2C2...
  10. Smith C, McClive P, Hudson Q, Sinclair A. Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling. Dev Biol. 2005;284:337-50 pubmed
    ..Taken together, these studies indicate that a key cellular event in gonadal sex differentiation is conserved among higher vertebrates, that it involves PDGF signalling, and that in mammals is an indirect effect of Sry expression. ..
  11. Zelinka C, Scott M, Volkov L, Fischer A. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1. PLoS ONE. 2012;7:e44477 pubmed publisher
    ..We conclude that the abundance, reactivity and retinal distribution of NIRG cells can be dynamic, are regulated by homoestatic mechanisms and are tethered to the microglia. ..
  12. Theodosiou N, Tabin C. Sox9 and Nkx2.5 determine the pyloric sphincter epithelium under the control of BMP signaling. Dev Biol. 2005;279:481-90 pubmed
    ..In this paper, we show that in the chick, the SRY-related transcription factor Sox9 is a marker for the posterior gizzard...
  13. Montero J, Lorda Diez C, Francisco Morcillo J, Chimal Monroy J, Garcia Porrero J, Hurle J. Sox9 Expression in Amniotes: Species-Specific Differences in the Formation of Digits. Front Cell Dev Biol. 2017;5:23 pubmed publisher
    ..These facts illustrate the plasticity of embryonic limb autopods. Sox9 is a precocious marker of skeletal differentiation of limb mesenchymal cells...