Gene Symbol: RAF1
Description: Raf-1 proto-oncogene, serine/threonine kinase
Alias: RAF proto-oncogene serine/threonine-protein kinase, C-RAF, MIL proto-oncogene serine/threonine-protein kinase, c-mil protein, v-raf-1 murine leukemia viral oncogene homolog 1
Dozier C, Denhez F, Henry C, Coll J, Begue A, Quatannens B, et al
. Alternative splicing of RNAs transcribed from the chicken c-mil gene. Mol Cell Biol. 1988;8:1835-8 pubmed
..These mRNA molecules can be translated into two distinct proteins of 73 and 71 kilodaltons. ..
Jansen H, Bister K. Nucleotide sequence analysis of the chicken gene c-mil, the progenitor of the retroviral oncogene v-mil. Virology. 1985;143:359-67 pubmed
..At both sites, no significant homologies were found between the sequence elements involved in the recombination. ..
Koenen M, Sippel A, Trachmann C, Bister K. Primary structure of the chicken c-mil protein:identification of domains shared with or absent from the retroviral v-mil protein. Oncogene. 1988;2:179-85 pubmed
Brummer T, Shaw P, Reth M, Misawa Y. Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J. 2002;21:5611-22 pubmed
..Our study shows that BCR-mediated ERK activation involves a cooperation of both B-Raf and Raf-1, which are activated specifically in a temporally distinct manner. ..
Flordellis C, Kan N, Lautenberger J, Samuel K, Garon C, Papas T. Analysis of the cellular proto-oncogene mht/raf: relationship to the 5' sequences of v-mht in avian carcinoma virus MH2 and v-raf in murine sarcoma virus 3611. Virology. 1985;141:267-74 pubmed
..Thus the v-mht oncogene is a subset of its normal cellular homolog in that it lacks intervening sequences and possibly lacks 5'-coding sequences. ..
Brummer T, Stehelin D, Misawa Y, Reth M. A revised and complete map of the chicken c-mil/raf-1 locus. Oncogene. 2004;23:3128-31 pubmed
Magarinos M, Aburto M, Sanchez Calderon H, Muñoz Agudo C, Rapp U, Varela Nieto I. RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development. PLoS ONE. 2010;5:e14435 pubmed publisher
..We conclude that RAF kinase activity is essential to establish the balance between cell proliferation and death in neuroepithelial otic precursors, and for otic neuron differentiation and axonal growth at the AVG. ..