Gene Symbol: PPARG
Description: peroxisome proliferator-activated receptor gamma
Alias: PPARgamma, peroxisome proliferator-activated receptor gamma, peroxisome proliferative activated receptor, gamma
Species: chicken
Products:     PPARG

Top Publications

  1. Sato K, Fukao K, Seki Y, Akiba Y. Expression of the chicken peroxisome proliferator-activated receptor-gamma gene is influenced by aging, nutrition, and agonist administration. Poult Sci. 2004;83:1342-7 pubmed
    Peroxisome proliferatior-activated receptor-gamma (PPARgamma) is a transcription factor that modulates lipid and glucose metabolism in mammals...
  2. Navidshad B, Royan M. Ligands and Regulatory Modes of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Avians. Crit Rev Eukaryot Gene Expr. 2015;25:287-92 pubmed
    ..The most important metabolic effect of PPARγ in chicken is its task in adipogenesis. Reviewing the ligands of chicken PPARγ gene can be useful to a better understanding of PPARγ regulatory functions. ..
  3. Sun Y, Gao Y, Qiao S, Wang S, Duan K, Wang Y, et al. Epigenetic DNA methylation in the promoters of peroxisome proliferator-activated receptor ? in chicken lines divergently selected for fatness. J Anim Sci. 2014;92:48-53 pubmed publisher
    ..0001). In conclusion, our findings suggest that chicken PPAR? is regulated by DNA methylation during adipose tissue development. ..
  4. Fu R, Liu R, Zhao G, Zheng M, Chen J, Wen J. Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens. Gene. 2014;537:120-5 pubmed publisher
    ..Taken together, all five transcription factors studied play roles in lipid metabolism in chickens with C/EBP? and PPAR? being important effectors. ..
  5. Wang L, Na W, Wang Y, Wang Y, Wang N, Wang Q, et al. [Characterization of chicken PPAR? expression and its impact on adipocyte proliferation and differentiation]. Yi Chuan. 2012;34:454-64 pubmed
    ..05). In summary, PPAR? gene may be related to the broiler abdominal fat deposition, and be probably a key regulator of chicken adipocyte proliferation and differentiation. ..
  6. Ye F, Lemieux H, Hoppel C, Hanson R, Hakimi P, Croniger C, et al. Peroxisome proliferator-activated receptor ? (PPAR?) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem. 2011;286:40013-24 pubmed publisher
    ..Moreover, we found that Ski co-immunoprecipitates with PPAR? and co-activates PPAR?-driven transcription...
  7. Larkina T, Sazanova A, Fomichev K, Barkova O, Malewski T, Jaszczak K, et al. HMG1A and PPARG are differently expressed in the liver of fat and lean broilers. J Appl Genet. 2011;52:225-8 pubmed publisher
    ..70, P ? 0.01) and abdominal fat weight (0.70, P ? 0.01). The peroxisome proliferator-activated receptor gamma (PPARG) gene was also up-regulated in the liver with a ratio of means of 3.34 (P ? 0...
  8. Sato K, Abe H, Kono T, Yamazaki M, Nakashima K, Kamada T, et al. Changes in peroxisome proliferator-activated receptor gamma gene expression of chicken abdominal adipose tissue with different age, sex and genotype. Anim Sci J. 2009;80:322-7 pubmed publisher
    Peroxisome proliferatior-activated receptor gamma (PPARgamma) is a transcription factor that regulates adipocyte differentiation, and the activation of PPARgamma increases fat deposition in growing chickens...
  9. Wang J, Li S, Li J, Zhang J, Xu S. Effects of cold stress on the messenger ribonucleic acid levels of peroxisome proliferator-activated receptor-{gamma} in spleen, thymus, and bursa of Fabricius of chickens. Poult Sci. 2009;88:2549-54 pubmed publisher
    ..The magnitude and direction of change in PPAR-gamma gene expression differs with the type of cold stress applied and also varies by tissue. ..

More Information


  1. Hu G, Wang S, Wang Z, Li Y, Li H. Genetic epistasis analysis of 10 peroxisome proliferator-activated receptor ?-correlated genes in broiler lines divergently selected for abdominal fat content. Poult Sci. 2010;89:2341-50 pubmed publisher
    ..Our results suggest that C/EBP? c.552G>A might be the most important locus contributing to phenotypic variation in AFW among all the polymorphisms detected in this study. ..
  2. Liu S, Wang Y, Wang L, Wang N, Li Y, Li H. Transdifferentiation of fibroblasts into adipocyte-like cells by chicken adipogenic transcription factors. Comp Biochem Physiol A Mol Integr Physiol. 2010;156:502-8 pubmed publisher
    ..In mammals, ectopic expression of adipogenic transcription factors C/EBPalpha, PPARgamma and SREBP-1 can induce transdifferentiation of a variety of different cell types into adipocyte-like cells...
  3. Ding N, Gao Y, Wang N, Li H. Functional analysis of the chicken PPAR? gene 5'-flanking region and C/EBP?-mediated gene regulation. Comp Biochem Physiol B Biochem Mol Biol. 2011;158:297-303 pubmed publisher
    ..Our results demonstrate that PPAR? can be directly regulated by C/EBP? in chickens. ..
  4. Shi H, Zhang Q, Wang Y, Yang P, Wang Q, Li H. Chicken adipocyte fatty acid-binding protein knockdown affects expression of peroxisome proliferator-activated receptor ? gene during oleate-induced adipocyte differentiation. Poult Sci. 2011;90:1037-44 pubmed publisher
    ..05). The present study suggested that the A-FABP knockdown might lead to decreased lipid accumulation and upregulated expression of PPAR-? in chicken adipocytes. ..
  5. Sato K, Matsushita K, Matsubara Y, Kamada T, Akiba Y. Adipose tissue fat accumulation is reduced by a single intraperitoneal injection of peroxisome proliferator-activated receptor gamma agonist when given to newly hatched chicks. Poult Sci. 2008;87:2281-6 pubmed publisher
    Peroxisome proliferator-activated receptor gamma (PPARgamma) is a transcription factor that regulates adipocyte differentiation and modulates lipid metabolism in mammals...
  6. Mu Y, Li H, Ding N, Wang Q, Wang Y, Wang S, et al. Peroxisome proliferator-activated receptor-gamma gene: a key regulator of adipocyte differentiation in chickens. Poult Sci. 2008;87:226-32 pubmed publisher
    ..The current study was designed to investigate the function and regulatory mechanism of PPARgamma in chicken adipogenesis by RNA interference...
  7. Huang J, Zhang Y, Zhou Y, Wan X, Zhang J. Effects of epigallocatechin gallate on lipid metabolism and its underlying molecular mechanism in broiler chickens. J Anim Physiol Anim Nutr (Berl). 2015;99:719-27 pubmed publisher
    ..The results suggest that EGCG could alleviate fat deposition in broilers through inhibiting fat anabolism and stimulating lipid catabolism in broilers. ..
  8. Duan K, Sun Y, Zhang X, Zhang T, Zhang W, Zhang J, et al. Identification and characterization of transcript variants of chicken peroxisome proliferator-activated receptor gamma. Poult Sci. 2015;94:2516-27 pubmed publisher
    ..05). This is the first report of transcript variants and protein isoforms of cPPARγ gene. Our findings provided a foundation for future investigations of the function and regulation of cPPARγ gene in adipose tissue development. ..
  9. Takada I, Yu R, Xu H, Lambert M, Montana V, Kliewer S, et al. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Mol Endocrinol. 2000;14:733-40 pubmed