Gene Symbol: PPARA
Description: peroxisome proliferator activated receptor alpha
Alias: PPAR, peroxisome proliferator-activated receptor alpha, PPAR alpha, peroxisome proliferative activated receptor, alpha, proliferator-activated receptor alpha
Diot C, Douaire M. Characterization of a cDNA sequence encoding the peroxisome proliferator activated receptor alpha in the chicken. Poult Sci. 1999;78:1198-202 pubmed
..A partial complementary deoxyribonucleic acid clone encoding a PPAR alpha from chicken liver was isolated and sequenced...
Jiang Q, Lust R, DeWitt J. Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor ? (PPAR?) and bone morphorgenic protein 2 (BMP2) pathways involved?. J Toxicol Environ Health A. 2013;76:635-50 pubmed publisher
..developmental toxicity in animal models through activation of the peroxisome proliferator-activated receptor ? (PPAR?)...
Huang J, Zhang Y, Zhou Y, Wan X, Zhang J. Effects of epigallocatechin gallate on lipid metabolism and its underlying molecular mechanism in broiler chickens. J Anim Physiol Anim Nutr (Berl). 2015;99:719-27 pubmed publisher
..The results suggest that EGCG could alleviate fat deposition in broilers through inhibiting fat anabolism and stimulating lipid catabolism in broilers. ..
Honda K, Saneyasu T, Sugimoto H, Kurachi K, Takagi S, Kamisoyama H. Role of peroxisome proliferator-activated receptor alpha in the expression of hepatic fatty acid oxidation-related genes in chickens. Anim Sci J. 2016;87:61-6 pubmed publisher
..In mammals, proliferator-activated receptor alpha (PPARÎ±), a transcription factor, plays an essential role in the regulation of hepatic fatty acid oxidation...
Takada I, Yu R, Xu H, Lambert M, Montana V, Kliewer S, et al
. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Mol Endocrinol. 2000;14:733-40 pubmed
..The PPAR alpha and gamma subtypes are well conserved from Xenopus to man, but the beta/delta subtypes display substantial ..
Cwinn M, Jones S, Kennedy S. Exposure to perfluorooctane sulfonate or fenofibrate causes PPAR-alpha dependent transcriptional responses in chicken embryo hepatocytes. Comp Biochem Physiol C Toxicol Pharmacol. 2008;148:165-71 pubmed publisher
..which occurs subsequent to activation of the nuclear receptor peroxisome proliferator activated receptor-alpha (PPAR-alpha). Activated PPAR-alpha up-regulates PPAR-alpha target genes, most of which are involved in lipid metabolism...
Fu R, Liu R, Zhao G, Zheng M, Chen J, Wen J. Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens. Gene. 2014;537:120-5 pubmed publisher
..As for the expression profiles of key transcription factors: 1) expression of C/EBP? and PPAR? in abdominal fat was significantly higher than that in breast and thigh muscles at all ages...
Zhang Z, Bi M, Yao H, Fu J, Li S, Xu S. Effect of cold stress on expression of AMPKalpha-PPARalpha pathway and inflammation genes. Avian Dis. 2014;58:415-26 pubmed
..These results suggested that increased inflammation was a feature associated with a lipid-metabolism disorder in the livers of chickens exposed to cold stress. ..