PGR

Summary

Gene Symbol: PGR
Description: progesterone receptor
Alias: NR3C3, progesterone receptor, nuclear receptor subfamily 3 group C member 3
Species: chicken
Products:     PGR

Top Publications

  1. Conneely O, Kettelberger D, Tsai M, Schrader W, O Malley B. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem. 1989;264:14062-4 pubmed
    The chicken progesterone receptor A and B proteins differ by an additional 128 amino acids located at the N terminus of the B protein...
  2. Schuchard M, Rejman J, McCormick D, Gosse B, Ruesink T, Spelsberg T. Characterization of a purified chromatin acceptor protein (receptor binding factor 1) for the avian oviduct progesterone receptor. Biochemistry. 1991;30:4535-42 pubmed
    The specific, high-affinity binding of the avian oviduct progesterone receptor (PR) with target-cell nuclei and chromatin has been shown to involve DNA complexed with specific chromatin acceptor proteins...
  3. Denner L, Schrader W, O Malley B, Weigel N. Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites. J Biol Chem. 1990;265:16548-55 pubmed
    ..in situ progesterone treatment in the regulation of site-specific phosphorylation of the chicken oviduct progesterone receptor (PR)...
  4. Felts S, Karnitz L, Toft D. Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR). Cell Stress Chaperones. 2007;12:353-63 pubmed
    ..Chk1, we performed a side-by-side comparison of the Hsp90-dependent chaperoning of Chk1 to that of the progesterone receptor (PR) and show that these distinct types of clients have different chaperoning requirements...
  5. Camacho Arroyo I, Hernández Molina V, Rivas Suárez M, Guerra Araiza C, González Morán M. Changes in progesterone receptor isoforms content in the brain of immature, mature and aged male and female chickens. Gen Comp Endocrinol. 2007;150:381-5 pubmed
  6. Kost S, Smith D, Sullivan W, Welch W, Toft D. Binding of heat shock proteins to the avian progesterone receptor. Mol Cell Biol. 1989;9:3829-38 pubmed
    The protein composition of the avian progesterone receptor was analyzed by immune isolation of receptor complexes and gel electrophoresis of the isolated proteins...
  7. Mehrotra J, Ganpat M, Kanaan Y, Fackler M, McVeigh M, Lahti Domenici J, et al. Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. Clin Cancer Res. 2004;10:2052-7 pubmed
    ..in DNA from 67 AA and 44 Cau invasive ductal breast cancers, stratified by age and estrogen receptor/progesterone receptor (ER/PR) status, by methylation-specific PCR...
  8. Camacho Arroyo I, González Arenas A, González Agüero G, Guerra Araiza C, González Morán G. Changes in the content of progesterone receptor isoforms and estrogen receptor alpha in the chick brain during embryonic development. Comp Biochem Physiol A Mol Integr Physiol. 2003;136:447-52 pubmed
  9. Huckaby C, Conneely O, Beattie W, Dobson A, Tsai M, O Malley B. Structure of the chromosomal chicken progesterone receptor gene. Proc Natl Acad Sci U S A. 1987;84:8380-4 pubmed
    We have isolated cosmid clones containing the chromosomal chicken progesterone receptor gene. The gene consists of eight exons and is approximately 38 kilobases long...

More Information

Publications31

  1. Zhuang Y, Landers J, Schuchard M, Syvala H, Gosse B, Ruesink T, et al. Immunohistochemical localization of the avian progesterone receptor and its candidate receptor binding factor (RBF-1). J Cell Biochem. 1993;53:383-93 pubmed
    ..6-10 kDa size range has been implicated to function in the cell-free nuclear binding of the avian oviduct progesterone receptor (PR)...
  2. González Morán M. Changes in progesterone receptor isoforms expression and in the morphology of the oviduct magnum of mature laying and aged nonlaying hens. Biochem Biophys Res Commun. 2016;478:999-1005 pubmed publisher
    The aim of this study was to evaluate changes in the morphology and expression of progesterone receptor (PR) isoforms in different cell subpopulations of the magnum region of the left oviduct of mature laying and aged nonlaying hens ..
  3. Schuchard M, Subramaniam M, Ruesink T, Spelsberg T. Nuclear matrix localization and specific matrix DNA binding by receptor binding factor 1 of the avian oviduct progesterone receptor. Biochemistry. 1991;30:9516-22 pubmed
    A chromatin acceptor protein for the avian oviduct progesterone receptor (PR), termed receptor binding factor 1 (RBF-1), has recently been shown to (1) be a component of the nuclear binding sites (acceptor sites) for PR and (2) generate ..
  4. Ocón Grove O, Maddineni S, Hendricks G, Elkin R, Proudman J, Ramachandran R. Pituitary progesterone receptor expression and plasma gonadotrophin concentrations in the reproductively dysfunctional mutant restricted ovulator chicken. Domest Anim Endocrinol. 2007;32:201-15 pubmed
    ..to wild-type (WT) hens, we hypothesized that RO hens would have an increased abundance of pituitary progesterone receptor (PR) mRNA and PR isoforms A and B as well as alterations in circulating gonadotrophin levels...
  5. Weaver A, Sullivan W, Felts S, Owen B, Toft D. Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J Biol Chem. 2000;275:23045-52 pubmed
    ..This tail is not needed for the binding of p23 to hsp90 or to complexes with the progesterone receptor. However, the tail is necessary for optimum active chaperoning of the progesterone receptor, as well as ..
  6. Smith D, Sullivan W, Marion T, Zaitsu K, Madden B, McCormick D, et al. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol Cell Biol. 1993;13:869-76 pubmed
    ..This p60 is the same protein previously identified in certain assembly complexes of chick progesterone receptor generated in a cell-free reconstitution system...
  7. Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
    Immunoprecipitation of unactivated avian progesterone receptor results in the copurification of hsp90, hsp70, and three additional proteins, p54, p50, and p23...
  8. Birnbaumer M, Hinrichs Rosello M, Cook R, Schrader W, O Malley B. Chemical and antigenic properties of pure 108,000 molecular weight chick progesterone receptor. Mol Endocrinol. 1987;1:249-59 pubmed
    Previous purifications of the progesterone receptor have yielded inadequate amounts of pure protein along with significant amounts of a nonreceptor contaminant...
  9. Jeltsch J, Turcotte B, Garnier J, Lerouge T, Krozowski Z, Gronemeyer H, et al. Characterization of multiple mRNAs originating from the chicken progesterone receptor gene. Evidence for a specific transcript encoding form A. J Biol Chem. 1990;265:3967-74 pubmed
    The structure of the 42-kilobase (kb) long chicken progesterone receptor (cPR) gene and of all six transcripts that are detectable on Northern blots was determined...
  10. Bai W, Tullos S, Weigel N. Phosphorylation of Ser530 facilitates hormone-dependent transcriptional activation of the chicken progesterone receptor. Mol Endocrinol. 1994;8:1465-73 pubmed
    ..In this study, one of the hormone-induced phosphorylation sites of chicken progesterone receptor, Ser530, was mutated to alanine, a nonphosphorylatable amino acid, and the transcriptional activity of the ..
  11. Sullivan W, Vroman B, Bauer V, Puri R, Riehl R, Pearson G, et al. Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies. Biochemistry. 1985;24:4214-22 pubmed
    Previous studies have shown that the molybdate-stabilized progesterone receptor from the chick oviduct contains a nonhormone binding component with a molecular weight of 90 000...
  12. Gronemeyer H, Turcotte B, Quirin Stricker C, Bocquel M, Meyer M, Krozowski Z, et al. The chicken progesterone receptor: sequence, expression and functional analysis. EMBO J. 1987;6:3985-94 pubmed
    The complete mRNA sequence of the chicken progesterone receptor (cPR) has been determined. Expression of the cloned cDNA both in vivo and in vitro produces a protein that has the same apparent mol...
  13. Conneely O, Sullivan W, Toft D, Birnbaumer M, Cook R, Maxwell B, et al. Molecular cloning of the chicken progesterone receptor. Science. 1986;233:767-70 pubmed
    To define the functional domains of the progesterone receptor required for gene regulation, complementary DNA (cDNA) clones encoding the chicken progesterone receptor have been isolated from a chicken oviduct lambda gt11 cDNA expression ..
  14. Jeltsch J, Krozowski Z, Quirin Stricker C, Gronemeyer H, Simpson R, Garnier J, et al. Cloning of the chicken progesterone receptor. Proc Natl Acad Sci U S A. 1986;83:5424-8 pubmed
    Monospecific antibodies directed against the chicken progesterone receptor (PR) form B were used to screen a randomly primed phage lambda gt11 cDNA expression library prepared from size-fractionated chicken oviduct mRNA...
  15. Olbrich L, Wessel L, Balakrishnan Renuka A, Böing M, Brand Saberi B, Theiss C. Rapid impact of progesterone on the neuronal growth cone. Endocrinology. 2013;154:3784-95 pubmed publisher
    ..Thus, we could demonstrate for the first time that classical progesterone receptor (PR) A and B and the recently described progesterone receptor membrane component 1 (PGRMC1) are expressed ..
  16. Milad M, Sullivan W, Diehl E, Altmann M, Nordeen S, Edwards D, et al. Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol Endocrinol. 1995;9:838-47 pubmed
    ..human breast carcinoma cells and the chicken oviduct were used to study the structure of the nonactivated progesterone receptor (PR) complex...
  17. Bai W, Weigel N. Phosphorylation of Ser211 in the chicken progesterone receptor modulates its transcriptional activity. J Biol Chem. 1996;271:12801-6 pubmed
    The chicken progesterone receptor has been shown to be phosphorylated in vivo at four major sites...
  18. Simpson R, Grego B, Govindan M, Gronemeyer H. Peptide sequencing of the chick oviduct progesterone receptor form B. Mol Cell Endocrinol. 1987;52:177-84 pubmed
    The progesterone receptor form B has been isolated to apparent homogeneity from large scale preparations of laying hen oviduct cytosol. The quantities obtained were sufficient to monitor the separation of tryptic peptides on HPLC columns...
  19. Haverinen M, Passinen S, Syvala H, Pasanen S, Manninen T, Tuohimaa P, et al. Heat shock protein 90 and the nuclear transport of progesterone receptor. Cell Stress Chaperones. 2001;6:256-62 pubmed
    ..We demonstrate that the stabilized oligomeric complex of progesterone receptor (PR) cannot be transported into the nucleus and that unliganded PR salt dissociated from Hsp90 is ..
  20. Passinen S, Ylikomi T. Evidence for the existence of an oligomeric, non-DNA-binding complex of the progesterone receptor in the cytoplasm. Eur J Histochem. 2003;47:201-8 pubmed
    ..The complex was studied with an antibody (aD) recognizing only the dissociated form of the chicken progesterone receptor (PR) and with antibodies (PR22, PR6). Recognizing also oligomeric forms of the receptor...
  21. Conneely O, Dobson A, Tsai M, Beattie W, Toft D, Huckaby C, et al. Sequence and expression of a functional chicken progesterone receptor. Mol Endocrinol. 1987;1:517-25 pubmed
    We have cloned and sequenced 4.5 kilobases (Kb) of cDNA encoding the chicken progesterone receptor. The complete cDNA contains an open reading frame of 2361 nucleotides in length and encodes a polypeptide of 787 amino acids with a mol wt ..
  22. González Morán M. Immunohistochemical localization of progesterone receptor isoforms and estrogen receptor alpha in the chicken oviduct magnum during development. Acta Histochem. 2015;117:681-7 pubmed publisher
    In this work, the immunohistochemical expression of progesterone receptor (PR) isoforms and estrogen receptor alpha (ER-α), as well as the histomorphometric changes of the magnum region of the left oviduct from 8-day-old chicken ..