Gene Symbol: PAX6
Description: paired box 6
Alias: PAX-6, paired box protein Pax-6, paired box gene 6
Species: chicken
Products:     PAX6

Top Publications

  1. Li H, Yang J, Jacobson R, Pasko D, Sundin O. Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: implications for stepwise determination of the lens. Dev Biol. 1994;162:181-94 pubmed
    ..Our results raise the possibility that Pax-6 may be involved in the early establishment of lens-competent regions within the head ectoderm. ..
  2. Kawakami A, Kimura Kawakami M, Nomura T, Fujisawa H. Distributions of PAX6 and PAX7 proteins suggest their involvement in both early and late phases of chick brain development. Mech Dev. 1997;66:119-30 pubmed
    We describe here the isolation of chicken PAX6 and PAX7 as members of the PAX gene family expressed in late stages of chick nervous system development...
  3. Austdal L, Bjørnstad S, Mathisen G, Aden P, Mikkola I, Paulsen R, et al. Glucocorticoid Effects on Cerebellar Development in a Chicken Embryo Model: Exploring Changes in PAX6 and Metalloproteinase-9 After Exposure to Dexamethasone. J Neuroendocrinol. 2016;28: pubmed publisher
    ..g. autism). Transcription factor PAX6 and matrix metalloproteinase-9 (MMP-9) are critical for normal cerebellar development and are highly expressed in ..
  4. Lleras Forero L, Tambalo M, Christophorou N, Chambers D, Houart C, Streit A. Neuropeptides: developmental signals in placode progenitor formation. Dev Cell. 2013;26:195-203 pubmed publisher
    ..Somatostatin controls ectodermal expression of nociceptin, and both peptides regulate Pax6 in lens and olfactory progenitors...
  5. Bhat S, Rayner S, Chau S, Ariyasu R. Pax-6 expression in posthatch chick retina during and recovery from form-deprivation myopia. Dev Neurosci. 2004;26:328-35 pubmed
  6. Kataoka K, Yoshitomo Nakagawa K, Shioda S, Nishizawa M. A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities. J Biol Chem. 2001;276:819-26 pubmed
    ..b>Pax6, whose homeodomain is relatively similar to MHox, also could interact with Maf...
  7. Azuma N, Tadokoro K, Asaka A, Yamada M, Yamaguchi Y, Handa H, et al. The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure. Hum Mol Genet. 2005;14:735-45 pubmed
    ..The transcription factor Pax6 is a master regulator of eye development...
  8. Canto Soler M, Adler R. Optic cup and lens development requires Pax6 expression in the early optic vesicle during a narrow time window. Dev Biol. 2006;294:119-32 pubmed
    b>Pax6 mutations cause complex ocular malformations, but it is uncertain whether early eye development normally requires Pax6 function in both the optic vesicle (OV) and the lens epithelium, or only in the latter...
  9. Wakamatsu Y. Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo. Dev Growth Differ. 2011;53:994-1003 pubmed publisher
    ..In this study, I show that Pax6 is initially expressed in the preplacodal region at the level of ophthalmic trigeminal placode, and that this ..

More Information


  1. Kayam G, Kohl A, Magen Z, Peretz Y, Weisinger K, Bar A, et al. A novel role for Pax6 in the segmental organization of the hindbrain. Development. 2013;140:2190-202 pubmed publisher
    ..b>Pax6 is a highly conserved transcription factor crucial for neuronal development, yet little is known regarding its ..
  2. Reza H, Yasuda K. The involvement of neural retina pax6 in lens fiber differentiation. Dev Neurosci. 2004;26:318-27 pubmed
    ..The homeobox gene Pax6 is vitally important to the entire process of eye development in both vertebrates and invertebrates...
  3. Jensen A. Potential roles for BMP and Pax genes in the development of iris smooth muscle. Dev Dyn. 2005;232:385-92 pubmed
    ..Third, because humans and mice that are heterozygous for Pax6 mutations have no irides (Hill et al. [1991] Nature 354:522-525; Hanson et al. [1994] Nat. Genet...
  4. Reza H, Takahashi Y, Yasuda K. Stage-dependent expression of Pax6 in optic vesicle/cup regulates patterning genes through signaling molecules. Differentiation. 2007;75:726-36 pubmed
    Dorso-ventral and proximo-distal axis formation of the optic cup is apparent from early stages of development. Pax6 is initially detectable in the optic vesicle and later shows a distal-high and proximal-low gradient of expression in the ..
  5. Robertshaw E, Matsumoto K, Lumsden A, Kiecker C. Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus. Proc Natl Acad Sci U S A. 2013;110:E3919-26 pubmed publisher
    ..expression of two transcription factors: Iroquois-related homeobox gene 3 (Irx3) posterior to the ZLI, and paired box gene 6 (Pax6) anterior to the forebrain-midbrain boundary...
  6. Di Lullo E, Haton C, Le Poupon C, Volovitch M, Joliot A, Thomas J, et al. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development. 2011;138:4991-5001 pubmed publisher
    ..Here, we have used the embryonic chick neural tube to investigate a possible role for homeoprotein Pax6 transfer in oligodendrocyte precursor cell (OPC) migration...
  7. Spence J, Madhavan M, Aycinena J, Del Rio Tsonis K. Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6. Mol Vis. 2007;13:57-65 pubmed
    ..chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf...
  8. Zhang S, Li Y, Tan R, Tsoi B, Huang W, Huang Y, et al. A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo. Dis Model Mech. 2016;9:177-86 pubmed publisher
    ..3% of embryonic eye malformation happened on EDD 5. In this model, the key genes regulating eye development, Pax6, Six3 and Otx2, were downregulated by hyperglycemia...
  9. Tan R, Zhang S, Li Y, Tsoi B, Huang W, Yao N, et al. Proanthocyanidins Prevent High Glucose-Induced Eye Malformation by Restoring Pax6 Expression in Chick Embryo. Nutrients. 2015;7:6567-81 pubmed publisher
    ..Moreover, the key genes regulating eye development, Pax6, was down-regulated by high glucose. Proanthocyanidins could restore the suppressed expression of Pax6...
  10. Sjödal M, Gunhaga L. Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke's pouch. Gene Expr Patterns. 2008;8:481-5 pubmed publisher
    ..acid producing enzyme Retinaldehyde dehydrogenase3 (Raldh3) and four transcription factors, Pitx2, Isl1, Lim3 and Pax6 in chick embryos from head fold stage to embryonic day (E) 4.5...
  11. Leconte L, Lecoin L, Martin P, Saule S. Pax6 interacts with cVax and Tbx5 to establish the dorsoventral boundary of the developing eye. J Biol Chem. 2004;279:47272-7 pubmed
    ..Misexpression of cVax or Tbx5 induces profound defects in eye morphology and abnormal visual projections. In the Pax6-/- mutant Tbx5 fails to be expressed, and Vax1 and -2 are abnormally present in the entire optic vesicle...
  12. Ohuchi H, Fukui H, Matsuyo A, Tomonari S, Tanaka M, Arai H, et al. Autotaxin controls caudal diencephalon-mesencephalon development in the chick. Dev Dyn. 2010;239:2647-58 pubmed publisher
    ..RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of ..
  13. Li X, Liu Z, Qiu M, Yang Z. Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord. Development. 2014;141:2875-84 pubmed publisher
    ..Here, we provide evidence that the zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary through mutually repressive interactions with the class II protein Nkx2-..
  14. Canto Soler M, Huang H, Romero M, Adler R. Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation. Dev Dyn. 2008;237:758-67 pubmed publisher
    We have hypothesized that the transcription factor CTCF may influence retinal cell differentiation by controlling Pax6 expression, because (1) CTCF has been shown to repress Pax6 expression in some tissues, and (2) Pax6 blocks the ..
  15. Inoue M, Kamachi Y, Matsunami H, Imada K, Uchikawa M, Kondoh H. PAX6 and SOX2-dependent regulation of the Sox2 enhancer N-3 involved in embryonic visual system development. Genes Cells. 2007;12:1049-61 pubmed
    ..The core sequence comprises a SOX-binding sequence and a non-canonical PAX6 (Paired domain) binding sequence, and is activated by the synergistic action of SOX2 and PAX6 in transfected cells...