Gene Symbol: PAX3
Description: paired box 3
Alias: paired box protein Pax-3, Paired-box transcription factor protein PAX3, paired box gene 3
Species: chicken
Products:     PAX3

Top Publications

  1. Matsunaga E, Araki I, Nakamura H. Role of Pax3/7 in the tectum regionalization. Development. 2001;128:4069-77 pubmed
    b>Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development...
  2. Cairns D, Sato M, Lee P, Lassar A, Zeng L. A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3. Dev Biol. 2008;323:152-65 pubmed publisher
    ..2. Forced expression of Nkx3.2 blocks somitic expression of the dermomyotomal marker Pax3 both in vitro and in vivo...
  3. Lin J, Wang C, Yang C, Fu S, Redies C. Pax3 and Pax7 interact reciprocally and regulate the expression of cadherin-7 through inducing neuron differentiation in the developing chicken spinal cord. J Comp Neurol. 2016;524:940-62 pubmed publisher
    b>Pax3 and Pax7 are closely related transcription factors that are widely expressed in the developing nervous system and somites. In the CNS, both genes are expressed in the dorsal part of the neural tube during development...
  4. Lin J, Redies C, Luo J. Regionalized expression of ADAM13 during chicken embryonic development. Dev Dyn. 2007;236:862-70 pubmed
    ..Furthermore, ADAM13 mRNA was also detected in several tissues and organs, such as the somites and their derived muscles, the meninges surrounding the spinal cord, the dorsal aorta, the developing kidney, and several digestive organs. ..
  5. Galli L, Knight S, Barnes T, Doak A, Kadzik R, Burrus L. Identification and characterization of subpopulations of Pax3 and Pax7 expressing cells in developing chick somites and limb buds. Dev Dyn. 2008;237:1862-74 pubmed publisher
    b>Pax3 and Pax7 are closely related paired-boxed family transcription factors that are known to play important roles in embryonic and adult myogenesis...
  6. Kirkpatrick L, Yablonka Reuveni Z, Rosser B. Retention of Pax3 expression in satellite cells of muscle spindles. J Histochem Cytochem. 2010;58:317-27 pubmed publisher
    ..During vertebrate embryogenesis, myogenic progenitors express both Pax7 and Pax3 proteins...
  7. Wakamatsu Y. Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo. Dev Growth Differ. 2011;53:994-1003 pubmed publisher
    ..b>Pax3 has been known as a marker for ophthalmic trigeminal placode specification, and also an important regulator of ..
  8. Agoston Z, Li N, Haslinger A, Wizenmann A, Schulte D. Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. BMC Dev Biol. 2012;12:10 pubmed publisher
    ..experimental evidence for reciprocal regulation and subsequent cooperation of the paired-type transcription factors Pax3, Pax7 and the TALE-homeodomain protein Meis2 in the tectal anlage...
  9. Cairns D, Liu R, Sen M, Canner J, Schindeler A, Little D, et al. Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS ONE. 2012;7:e39642 pubmed publisher
    ..Furthermore, ectopic expression of the myogenic factor Pax3 prevents chondrogenesis in these cells, while chondrogenic factors Nkx3...

More Information


  1. Adams J, Sudweeks S, Stark M. Pax3 isoforms in sensory neurogenesis: expression and function in the ophthalmic trigeminal placode. Dev Dyn. 2014;243:1249-61 pubmed publisher
    In the trigeminal placode, Pax3 is classified as necessary but not sufficient for sensory neuron differentiation. One hypothesis is that different Pax3 isoforms regulate cellular differentiation uniquely...
  2. Yin H, Li D, Zhang L, Yang M, Zhao X, Wang Y, et al. Housing system influences abundance of Pax3 and Pax7 in postnatal chicken skeletal muscles. Poult Sci. 2014;93:1337-43 pubmed publisher
    ..The objective of this study was to evaluate the effect of housing system on abundance of Pax3 and Pax7 in postnatal chicken skeletal muscles...
  3. Lin J, Fu S, Yang C, Redies C. Pax3 overexpression induces cell aggregation and perturbs commissural axon projection during embryonic spinal cord development. J Comp Neurol. 2017;525:1618-1632 pubmed publisher
    b>Pax3 is a transcription factor that belongs to the paired box family...