Gene Symbol: PAX2
Description: paired box 2
Alias: PAX-2, paired box protein Pax-2, paired box gene 2, paired-box containing protein Pax-2
Thanos S, Püttmann S, Naskar R, Rose K, Langkamp Flock M, Paulus W. Potential role of Pax-2 in retinal axon navigation through the chick optic nerve stalk and optic chiasm. J Neurobiol. 2004;59:8-23 pubmed
..These data suggest that balanced expression of Pax-2 results in the correct formation of the chick chiasm at early stages by imposing accurate pathfinding within the optic stalk and the midline. ..
Li H, Liu H, Corrales C, Mutai H, Heller S. Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear. J Neurobiol. 2004;60:61-70 pubmed
..Furthermore, the likelihood that Pax-2-expressing cells in the otocyst die by apoptosis is much lower when compared with cells residing in Pax-2-negative regions. ..
Hidalgo Sanchez M, Martinez de la Torre M, Alvarado Mallart R, Puelles L. A distinct preisthmic histogenetic domain is defined by overlap of Otx2 and Pax2 gene expression in the avian caudal midbrain. J Comp Neurol. 2005;483:17-29 pubmed
Correlative in situ hybridization of Otx2, Pax2, Gbx2, and Fgf8 mRNA probes in adjacent serial sections through the chicken midbrain and isthmus at early to intermediate stages of development served to map in detail the area of overlap of ..
Soukkarieh C, Agius E, Soula C, Cochard P. Pax2 regulates neuronal-glial cell fate choice in the embryonic optic nerve. Dev Biol. 2007;303:800-13 pubmed
..The optic nerve is characterized by expression of the homeodomain transcription factor Pax2 which is maintained in differentiated astrocytes...
Barembaum M, Bronner Fraser M. Pax2 and Pea3 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear. Dev Biol. 2010;340:222-31 pubmed publisher
..of putative transcription factor binding sites reveal that Pea3, a downstream effector of FGF signaling, and Pax2 directly activate spalt4 during ear development...
Sanchez Calderon H, Martin Partido G, Hidalgo Sanchez M. Pax2 expression patterns in the developing chick inner ear. Gene Expr Patterns. 2005;5:763-73 pubmed
..of the developing vertebrate inner ear could be determined by complex regulatory genetic pathways involving the Pax2/5/8 genes...
Sehgal R, Karcavich R, Carlson S, Belecky Adams T. Ectopic Pax2 expression in chick ventral optic cup phenocopies loss of Pax2 expression. Dev Biol. 2008;319:23-33 pubmed publisher
b>Pax2 is essential for the development of the urogenital system, neural tube, otic vesicle, optic cup and optic tract [Dressler, G.R., Deutsch, U., et al., 1990...
Warchol M, Richardson G. Expression of the Pax2 transcription factor is associated with vestibular phenotype in the avian inner ear. Dev Neurobiol. 2009;69:191-202 pubmed publisher
The paired-domain transcription factor Pax2 is involved in many facets of inner ear development, but relatively little is known about the expression or function of Pax2 in the mature ear...
Trevino L, Giles J, Wang W, Urick M, Johnson P. Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?. Horm Cancer. 2010;1:177-86 pubmed publisher
..These data suggest that chicken ovarian tumors may arise from alternative sites, including the oviduct...