ovomacroglobulin ovostatin


Gene Symbol: ovomacroglobulin ovostatin
Description: ovostatin
Alias: ovostatin, ovomacroglobulin, ovostatin
Species: chicken

Top Publications

  1. Nagase H, Harris E, Woessner J, Brew K. Ovostatin: a novel proteinase inhibitor from chicken egg white. I. Purification, physicochemical properties, and tissue distribution of ovostatin. J Biol Chem. 1983;258:7481-9 pubmed
    ..Monospecific antibody raised against the egg white inhibitor was employed to examine the tissue distribution of the inhibitor. The inhibitor was found only in oviduct and egg white, but not in other tissues or serum of chickens. ..
  2. Enghild J, Salvesen G, Brew K, Nagase H. Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cle. J Biol Chem. 1989;264:8779-85 pubmed
    The homologous proteinase inhibitors, human alpha 2-macroglobulin (alpha 2M) and chicken ovostatin, have been compared with respect to their "bait" region sequences and interactions with two human matrix metalloproteinases, ..
  3. Nielsen K, Sottrup Jensen L, Nagase H, Th√łgersen H, Etzerodt M. Amino acid sequence of hen ovomacroglobulin (ovostatin) deduced from cloned cDNA. DNA Seq. 1994;5:111-9 pubmed
    The complete amino acid sequence of the hen ovomacroglobulin (ovostatin) subunit has been determined from cDNA and partial peptide sequence analysis...
  4. Nielsen K, Sottrup Jensen L. Evidence from sequence analysis that hen egg-white ovomacroglobulin (ovostatin) is devoid of an internal beta-Cys-gamma-Glu thiol ester. Biochim Biophys Acta. 1993;1162:230-2 pubmed
    53 residues of the internal sequence from the proteinase-binding hen egg-white ovostatin have been determined. The stretch corresponds to residues 945-997 of human alpha 2-macroglobulin...
  5. Lim W, Jeong W, Kim J, Lee J, Kim J, Bazer F, et al. Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens. Reprod Biol Endocrinol. 2011;9:137 pubmed publisher
    Alpha 2 macroglobulin (A2M; also known as ovostatin), a homotetrameric protein with four disulfide-linked subunits, has the unique feature of inactivating/inhibiting most known proteases including serine-, threonine-, cysteine-, aspartic-..