Gene Symbol: OC-17
Description: ovocleidin 17
Species: chicken

Top Publications

  1. Hincke M, Tsang C, Courtney M, Hill V, Narbaitz R. Purification and immunochemistry of a soluble matrix protein of the chicken eggshell (ovocleidin 17). Calcif Tissue Int. 1995;56:578-83 pubmed
    ..Our results indicate that this protein is secreted during shell formation and becomes incorporated into this structure. It may therefore play a role in the crystallization process and influence the properties of the resulting eggshell...
  2. Reyes Grajeda J, Moreno A, Romero A. Crystal structure of ovocleidin-17, a major protein of the calcified Gallus gallus eggshell: implications in the calcite mineral growth pattern. J Biol Chem. 2004;279:40876-81 pubmed
    ..Determining the three-dimensional structure of OC17 contributes to a better understanding of the biological behavior of structurally related biomolecules and of the mechanisms involved in eggshell and other mineralization processes. ..
  3. Freeman C, Harding J, Quigley D, Rodger P. Protein binding on stepped calcite surfaces: simulations of ovocleidin-17 on calcite {31.16} and {31.8}. Phys Chem Chem Phys. 2012;14:7287-95 pubmed publisher
    ..Our analysis shows that it is unlikely that Ovocleidin-17 is important in controlling crystal morphology; its main role is likely to be in controlling calcite nucleation. ..
  4. Mann K, Siedler F. The amino acid sequence of ovocleidin 17, a major protein of the avian eggshell calcified layer. Biochem Mol Biol Int. 1999;47:997-1007 pubmed
    ..The most similar sequences with an average of 30% identical amino acids were those of pancreatic stone protein (lithostathine) and lectins and anticoagulant proteins from snake venom. ..
  5. Hincke M, Gautron J, Tsang C, McKee M, Nys Y. Molecular cloning and ultrastructural localization of the core protein of an eggshell matrix proteoglycan, ovocleidin-116. J Biol Chem. 1999;274:32915-23 pubmed
    ..Ovocleidin-116 thus is a candidate molecule for the regulation of calcite growth during eggshell calcification. ..
  6. Panheleux M, Nys Y, Williams J, Gautron J, Boldicke T, Hincke M. Extraction and quantification by ELISA of eggshell organic matrix proteins (ovocleidin-17, ovalbumin, ovotransferrin) in shell from young and old hens. Poult Sci. 2000;79:580-8 pubmed
    ..The quantification of specific eggshell matrix proteins in shell of differing quality is, therefore, a promising tool for analyzing the origin of eggshell faults and may provide useful information for breeding programs. ..
  7. Dominguez Vera J, Gautron J, Garcia Ruiz J, Nys Y. The effect of avian uterine fluid on the growth behavior of calcite crystals. Poult Sci. 2000;79:901-7 pubmed
    ..The majority of the corners became rough and developed curved faces. These observations confirm the interaction of the uterine fluid with calcite and its contribution to eggshell structure. ..
  8. Lakshminarayanan R, Joseph J, Kini R, Valiyaveettil S. Structure-function relationship of avian eggshell matrix proteins: a comparative study of two major eggshell matrix proteins, ansocalcin and OC-17. Biomacromolecules. 2005;6:741-51 pubmed
    ..To our knowledge, this is the first report on the comparison of properties of homologous eggshell proteins that belong to the same phylogeny. ..
  9. Miksik I, Eckhardt A, Sedláková P, Mikulikova K. Proteins of insoluble matrix of avian (gallus gallus) eggshell. Connect Tissue Res. 2007;48:1-8 pubmed
    ..The pigment (protoporphyrin IX) was mainly found in the cuticle and is incorporated into the protein network. ..

More Information


  1. Wellman Labadie O, Lakshminarayanan R, Hincke M. Antimicrobial properties of avian eggshell-specific C-type lectin-like proteins. FEBS Lett. 2008;582:699-704 pubmed publisher
    ..The results suggest that avian C-type lectin-like proteins may play an important antimicrobial role in defence of the avian embryo. ..
  2. Freeman C, Harding J, Quigley D, Rodger P. Structural control of crystal nuclei by an eggshell protein. Angew Chem Int Ed Engl. 2010;49:5135-7 pubmed publisher
  3. Zhang Q, Liu L, Zhu F, Ning Z, Hincke M, Yang N, et al. Integrating de novo transcriptome assembly and cloning to obtain chicken Ovocleidin-17 full-length cDNA. PLoS ONE. 2014;9:e93452 pubmed publisher
    ..We provide a general method for biologists experiencing difficulty in obtaining candidate gene full-length cDNA sequences...
  4. Reyes Grajeda J, Jáuregui Zúñiga D, Rodriguez Romero A, Hernandez Santoyo A, Bolanos Garcia V, Moreno A. Crystallization and preliminary x-ray analysis of ovocleidin-17 a major protein of the gallus gallus eggshell calcified layer. Protein Pept Lett. 2002;9:253-7 pubmed
    ..Crystals belong to one of the trigonal space group P3 with cell dimensions a= b= 59.53 A and c = 83.33 A, and alpha=beta= 90 degrees and gamma=120 degrees. Crystals diffract up to 3.0 A. ..
  5. Marié P, Labas V, Brionne A, Harichaux G, Hennequet Antier C, Nys Y, et al. Quantitative proteomics and bioinformatic analysis provide new insight into protein function during avian eggshell biomineralization. J Proteomics. 2015;113:178-93 pubmed publisher
    ..Better understanding of this process will provide insight into the fabrication of ceramics at ambient pressure and temperature. ..