Gene Symbol: NKX3-2
Description: NK3 homeobox 2
Alias: BAPX1, NKX-3.2, homeobox protein Nkx-3.2, NK class homeoprotein Nkx-3.2, bagpipe homeobox homolog 1
Provot S, Kempf H, Murtaugh L, Chung U, Kim D, Chyung J, et al
. Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development. 2006;133:651-62 pubmed
..In chick and mouse, expression of Nkx3.2/Bapx1 in the growth plate is restricted to the proliferative zone and is down regulated as chondrocyte maturation begins...
Cairns D, Sato M, Lee P, Lassar A, Zeng L. A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3. Dev Biol. 2008;323:152-65 pubmed publisher
..2 set up mutually repressing cell fates that promote either dermomyotome/myotome or sclerotome differentiation, respectively...
Nishida W, Nakamura M, Mori S, Takahashi M, Ohkawa Y, Tadokoro S, et al
. A triad of serum response factor and the GATA and NK families governs the transcription of smooth and cardiac muscle genes. J Biol Chem. 2002;277:7308-17 pubmed
..Our findings demonstrate that smooth and cardiac muscle have a shared transcriptional machinery and that the GATA and NK families confer muscle specificity on the serum response factor/CArG interaction. ..
Wilson J, Tucker A. Fgf and Bmp signals repress the expression of Bapx1 in the mandibular mesenchyme and control the position of the developing jaw joint. Dev Biol. 2004;266:138-50 pubmed
..the palatoquadrate and proximal part Meckel's cartilage (articular) has recently been shown to involve the gene Bapx1. Bapx1 is expressed in the developing mandibular arch in two distinct caudal, proximal patches, one on either side ..
Schneider A, Mijalski T, Schlange T, Dai W, Overbeek P, Arnold H, et al
. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos. Curr Biol. 1999;9:911-4 pubmed
..2 was expressed predominantly on the left side. Thus, NKX3.2 transcripts accumulate on opposite sides of mouse and chick embryos although, in both the mouse and chick, NKX3.2 expression is controlled by the L-R signalling pathways. ..
Rodriguez Esteban C, Capdevila J, Economides A, Pascual J, Ortiz A, Izpisua Belmonte J. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature. 1999;401:243-51 pubmed
..Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo. ..
Cairns D, Liu R, Sen M, Canner J, Schindeler A, Little D, et al
. Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS ONE. 2012;7:e39642 pubmed publisher
..Thus our in vitro and in vivo analyses suggest that the balance of Pax3, Nkx3.2 and Sox9 may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells, which may be important for fracture healing...
Faure S, Georges M, McKey J, Sagnol S, de Santa Barbara P. Expression pattern of the homeotic gene Bapx1 during early chick gastrointestinal tract development. Gene Expr Patterns. 2013;13:287-92 pubmed publisher
..Different studies demonstrated that Bapx1 (for bagpipe homeobox homolog 1) negatively regulates the BMP pathway, but its precise expression pattern during the development and the ..