MYB

Summary

Gene Symbol: MYB
Description: MYB proto-oncogene, transcription factor
Alias: c-myb, transcriptional activator Myb, c-myb proto-oncogene, myb proto-oncogene protein, proto-oncogene c-Myb, thymic c-myb protein, v-myb avian myeloblastosis viral oncogene homolog, v-myb myeloblastosis viral oncogene homolog, yolk sac c-myb protein
Species: chicken
Products:     MYB

Top Publications

  1. Vadasz S, Marquez J, Tulloch M, Shylo N, GARCIA CASTRO M. Pax7 is regulated by cMyb during early neural crest development through a novel enhancer. Development. 2013;140:3691-702 pubmed publisher
    ..Further analysis demonstrates that cMyb is able to interact with this enhancer and modulates reporter and endogenous early Pax7 expression; thus, cMyb is identified as a novel regulator of Pax7 in early NC development. ..
  2. Klempnauer K, Gonda T, Bishop J. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell. 1982;31:453-63 pubmed
    The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons)...
  3. Plachetka A, Chayka O, Wilczek C, Melnik S, Bonifer C, Klempnauer K. C/EBPbeta induces chromatin opening at a cell-type-specific enhancer. Mol Cell Biol. 2008;28:2102-12 pubmed publisher
    ..restricted to the myelomonocytic lineage of the hematopoietic system where it is regulated synergistically by the Myb and CCAAT/enhancer binding protein (C/EBP) factors...
  4. Gundelach H, Braas D, Klempnauer K. The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication. BMC Mol Biol. 2007;8:75 pubmed
    The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the transformation of myelomonocytic cells by avian myeloblastosis virus (AMV)...
  5. Lei W, Rushton J, Davis L, Liu F, Ness S. Positive and negative determinants of target gene specificity in myb transcription factors. J Biol Chem. 2004;279:29519-27 pubmed
    The A-Myb and c-Myb transcription factors share a highly conserved DNA-binding domain and activate the same promoters in reporter gene assays...
  6. Tanikawa J, Ichikawa Iwata E, Kanei Ishii C, Nakai A, Matsuzawa S, Reed J, et al. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J Biol Chem. 2000;275:15578-85 pubmed
    ..HSF3 is specifically activated in unstressed proliferating cells by direct binding to the c-myb proto-oncogene product (c-Myb), which plays an important role in cellular proliferation...
  7. Karafiat V, Dvorakova M, Krejci E, Kralova J, Pajer P, Snajdr P, et al. Transcription factor c-Myb is involved in the regulation of the epithelial-mesenchymal transition in the avian neural crest. Cell Mol Life Sci. 2005;62:2516-25 pubmed
    ..We show for the first time that the key hematopoietic factor c-Myb is synthesized in early chick embryos including the neural tissue and participates in the regulation of the trunk ..
  8. Sandberg M, Sutton S, Pletcher M, Wiltshire T, Tarantino L, Hogenesch J, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-66 pubmed
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  9. Kanei Ishii C, Nomura T, Tanikawa J, Ichikawa Iwata E, Ishii S. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J Biol Chem. 2004;279:44582-9 pubmed
    Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein ..
  10. Frampton J, Gibson T, Ness S, Doderlein G, Graf T. Proposed structure for the DNA-binding domain of the Myb oncoprotein based on model building and mutational analysis. Protein Eng. 1991;4:891-901 pubmed
    b>Myb-related proteins from plants to humans are characterized by a DNA-binding domain which contains two to three imperfect repeats of approximately 50 amino acids each...

Detail Information

Publications21

  1. Vadasz S, Marquez J, Tulloch M, Shylo N, GARCIA CASTRO M. Pax7 is regulated by cMyb during early neural crest development through a novel enhancer. Development. 2013;140:3691-702 pubmed publisher
    ..Further analysis demonstrates that cMyb is able to interact with this enhancer and modulates reporter and endogenous early Pax7 expression; thus, cMyb is identified as a novel regulator of Pax7 in early NC development. ..
  2. Klempnauer K, Gonda T, Bishop J. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell. 1982;31:453-63 pubmed
    The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons)...
  3. Plachetka A, Chayka O, Wilczek C, Melnik S, Bonifer C, Klempnauer K. C/EBPbeta induces chromatin opening at a cell-type-specific enhancer. Mol Cell Biol. 2008;28:2102-12 pubmed publisher
    ..restricted to the myelomonocytic lineage of the hematopoietic system where it is regulated synergistically by the Myb and CCAAT/enhancer binding protein (C/EBP) factors...
  4. Gundelach H, Braas D, Klempnauer K. The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication. BMC Mol Biol. 2007;8:75 pubmed
    The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the transformation of myelomonocytic cells by avian myeloblastosis virus (AMV)...
  5. Lei W, Rushton J, Davis L, Liu F, Ness S. Positive and negative determinants of target gene specificity in myb transcription factors. J Biol Chem. 2004;279:29519-27 pubmed
    The A-Myb and c-Myb transcription factors share a highly conserved DNA-binding domain and activate the same promoters in reporter gene assays...
  6. Tanikawa J, Ichikawa Iwata E, Kanei Ishii C, Nakai A, Matsuzawa S, Reed J, et al. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J Biol Chem. 2000;275:15578-85 pubmed
    ..HSF3 is specifically activated in unstressed proliferating cells by direct binding to the c-myb proto-oncogene product (c-Myb), which plays an important role in cellular proliferation...
  7. Karafiat V, Dvorakova M, Krejci E, Kralova J, Pajer P, Snajdr P, et al. Transcription factor c-Myb is involved in the regulation of the epithelial-mesenchymal transition in the avian neural crest. Cell Mol Life Sci. 2005;62:2516-25 pubmed
    ..We show for the first time that the key hematopoietic factor c-Myb is synthesized in early chick embryos including the neural tissue and participates in the regulation of the trunk ..
  8. Sandberg M, Sutton S, Pletcher M, Wiltshire T, Tarantino L, Hogenesch J, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-66 pubmed
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  9. Kanei Ishii C, Nomura T, Tanikawa J, Ichikawa Iwata E, Ishii S. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J Biol Chem. 2004;279:44582-9 pubmed
    Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein ..
  10. Frampton J, Gibson T, Ness S, Doderlein G, Graf T. Proposed structure for the DNA-binding domain of the Myb oncoprotein based on model building and mutational analysis. Protein Eng. 1991;4:891-901 pubmed
    b>Myb-related proteins from plants to humans are characterized by a DNA-binding domain which contains two to three imperfect repeats of approximately 50 amino acids each...
  11. Grasser F, Graf T, Lipsick J. Protein truncation is required for the activation of the c-myb proto-oncogene. Mol Cell Biol. 1991;11:3987-96 pubmed
    The protein product of the v-myb oncogene of avian myeloblastosis virus, v-Myb, differs from its normal cellular counterpart, c-Myb, by (i) expression under the control of a strong viral long terminal repeat, (ii) truncation of both its ..
  12. Leverson J, Ness S. Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanism. Mol Cell. 1998;1:203-11 pubmed
    The c-Myb protein is controlled by intramolecular interactions, and point mutations can enhance its oncogenic activity...
  13. Fu S, Ganter B, Lipsick J. Myb proteins inhibit fibroblast transformation by v-Rel. Mol Cancer. 2006;5:54 pubmed
    ..In this report, we demonstrate that both the v-myb retroviral oncogene, which causes leukemic transformation of hematopoietic cells, and the c-myb proto-oncogene can ..