MYB

Summary

Gene Symbol: MYB
Description: MYB proto-oncogene, transcription factor
Alias: c-myb, transcriptional activator Myb, c-myb proto-oncogene, myb proto-oncogene protein, proto-oncogene c-Myb, thymic c-myb protein, v-myb avian myeloblastosis viral oncogene homolog, v-myb myeloblastosis viral oncogene homolog, yolk sac c-myb protein
Species: chicken
Products:     MYB

Top Publications

  1. Vadasz S, Marquez J, Tulloch M, Shylo N, GARCIA CASTRO M. Pax7 is regulated by cMyb during early neural crest development through a novel enhancer. Development. 2013;140:3691-702 pubmed publisher
    ..Further analysis demonstrates that cMyb is able to interact with this enhancer and modulates reporter and endogenous early Pax7 expression; thus, cMyb is identified as a novel regulator of Pax7 in early NC development. ..
  2. Klempnauer K, Gonda T, Bishop J. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell. 1982;31:453-63 pubmed
    The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons)...
  3. Plachetka A, Chayka O, Wilczek C, Melnik S, Bonifer C, Klempnauer K. C/EBPbeta induces chromatin opening at a cell-type-specific enhancer. Mol Cell Biol. 2008;28:2102-12 pubmed publisher
    ..restricted to the myelomonocytic lineage of the hematopoietic system where it is regulated synergistically by the Myb and CCAAT/enhancer binding protein (C/EBP) factors...
  4. Gundelach H, Braas D, Klempnauer K. The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication. BMC Mol Biol. 2007;8:75 pubmed
    The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the transformation of myelomonocytic cells by avian myeloblastosis virus (AMV)...
  5. Gerondakis S, Bishop J. Structure of the protein encoded by the chicken proto-oncogene c-myb. Mol Cell Biol. 1986;6:3677-84 pubmed
    The retroviral oncogene v-myb arose by transduction of the chicken proto-oncogene c-myb. We isolated and sequenced cDNA that represents the entire coding domain of chicken c-myb...
  6. Lei W, Rushton J, Davis L, Liu F, Ness S. Positive and negative determinants of target gene specificity in myb transcription factors. J Biol Chem. 2004;279:29519-27 pubmed
    The A-Myb and c-Myb transcription factors share a highly conserved DNA-binding domain and activate the same promoters in reporter gene assays...
  7. Tanikawa J, Ichikawa Iwata E, Kanei Ishii C, Nakai A, Matsuzawa S, Reed J, et al. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J Biol Chem. 2000;275:15578-85 pubmed
    ..HSF3 is specifically activated in unstressed proliferating cells by direct binding to the c-myb proto-oncogene product (c-Myb), which plays an important role in cellular proliferation...
  8. Schuur E, Dasgupta P, Reddy E, Rabinovich J, Baluda M. Alternative splicing of the chicken c-myb exon 9A. Oncogene. 1993;8:1839-47 pubmed
    The c-myb gene products are thought to be regulators of cellular replication and of differentiation and heterogeneity may underlie their multiple functions...
  9. Karafiat V, Dvorakova M, Krejci E, Kralova J, Pajer P, Snajdr P, et al. Transcription factor c-Myb is involved in the regulation of the epithelial-mesenchymal transition in the avian neural crest. Cell Mol Life Sci. 2005;62:2516-25 pubmed
    ..We show for the first time that the key hematopoietic factor c-Myb is synthesized in early chick embryos including the neural tissue and participates in the regulation of the trunk ..

More Information

Publications21

  1. Sandberg M, Sutton S, Pletcher M, Wiltshire T, Tarantino L, Hogenesch J, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-66 pubmed
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  2. Kanei Ishii C, Nomura T, Tanikawa J, Ichikawa Iwata E, Ishii S. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J Biol Chem. 2004;279:44582-9 pubmed
    Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein ..
  3. Frampton J, Gibson T, Ness S, Doderlein G, Graf T. Proposed structure for the DNA-binding domain of the Myb oncoprotein based on model building and mutational analysis. Protein Eng. 1991;4:891-901 pubmed
    b>Myb-related proteins from plants to humans are characterized by a DNA-binding domain which contains two to three imperfect repeats of approximately 50 amino acids each...
  4. Hahn S, Hahn M, Hayward W. Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene. Mol Cell Biol. 1989;9:837-43 pubmed
    We mapped and sequenced three upstream exons of the chicken c-myb gene and the regions flanking the first coding exon...
  5. Dvorak M, Urbanek P, Bartunek P, Paces V, Vlach J, Pecenka V, et al. Transcription of the chicken myb proto-oncogene starts within a CpG island. Nucleic Acids Res. 1989;17:5651-64 pubmed
    The nucleotide sequence of an 8.2-kb DNA fragment from the 5' proximal part of the chicken myb proto-oncogene spanning 1761 nucleotides upstream and 6436 nucleotides downstream from a presumed c-myb initiation codon was determined. A 3...
  6. Soret J, Vellard M, Viegas Pequignot E, Apiou F, Dutrillaux B, Perbal B. Chromosomal reallocation of the chicken c-myb locus and organization of 3'-proximal coding exons. FEBS Lett. 1990;263:254-60 pubmed
    In the course of our studies concerning the tissue-specific expression of the c-myb proto-oncogene, we have established the nucleotide sequence of the chicken c-myb 3'-proximal coding exons...
  7. Grasser F, Graf T, Lipsick J. Protein truncation is required for the activation of the c-myb proto-oncogene. Mol Cell Biol. 1991;11:3987-96 pubmed
    The protein product of the v-myb oncogene of avian myeloblastosis virus, v-Myb, differs from its normal cellular counterpart, c-Myb, by (i) expression under the control of a strong viral long terminal repeat, (ii) truncation of both its ..
  8. Leverson J, Ness S. Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanism. Mol Cell. 1998;1:203-11 pubmed
    The c-Myb protein is controlled by intramolecular interactions, and point mutations can enhance its oncogenic activity...
  9. Rosson D, Reddy E. Nucleotide sequence of chicken c-myb complementary DNA and implications for myb oncogene activation. Nature. 1986;319:604-6 pubmed
    ..The latter sequences, termed v-myb, are responsible for the oncogenic properties of the virus...
  10. Urbanek P, Dvorak M, Bartunek P, Pecenka V, Paces V, Travnicek M. Nucleotide sequence of chicken myb proto-oncogene promoter region: detection of an evolutionarily conserved element. Nucleic Acids Res. 1988;16:11521-30 pubmed
    The nucleotide sequence of the chicken myb proto-oncogene putative promoter region was determined and compared with the corresponding sequence of the mouse c-myb gene (1)...
  11. Fu S, Ganter B, Lipsick J. Myb proteins inhibit fibroblast transformation by v-Rel. Mol Cancer. 2006;5:54 pubmed
    ..In this report, we demonstrate that both the v-myb retroviral oncogene, which causes leukemic transformation of hematopoietic cells, and the c-myb proto-oncogene can ..
  12. Soret J, Vellard M, Martinerie C, Perbal B. Organization of 5'-proximal c-myb exons in chicken DNA. Implications for c-myb tissue-specific transcription. FEBS Lett. 1988;232:227-34 pubmed
    The organization of 5'-proximal c-myb exons in chicken DNA has been established by restriction enzyme mapping and nucleotide sequencing...