Gene Symbol: MEIS2
Description: Meis homeobox 2
Alias: Meis2a.1, Meis2a.2, homeobox protein Meis2, Meis1, myeloid ecotropic viral integration site 1 homolog 2, homeoprotein Meis2a.1, homeoprotein Meis2a.2, myeloid ecotropic viral insertion site-2a protein
Heine P, Dohle E, Bumsted O Brien K, Engelkamp D, Schulte D. Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development. Development. 2008;135:805-11 pubmed publisher
..Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2 (Mrg1), in species-specific temporal sequences...
Capdevila J, Tsukui T, Rodríquez Esteban C, Zappavigna V, Izpisua Belmonte J. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol Cell. 1999;4:839-49 pubmed
..We show that restriction of expression of the homeobox gene Meis2 to proximal regions of the limb bud is essential for limb development, since ectopic Meis2 severely disrupts limb ..
Heine P, Dohle E, Schulte D. Sonic hedgehog signaling in the chick retina accelerates Meis2 downregulation simultaneously with retinal ganglion cell genesis. Neuroreport. 2009;20:279-84 pubmed publisher
..spatial-temporal expression and function of Drosophila melanogaster homothorax (hth) and its vertebrate homologue Meis2 in the eye anlage show a high degree of evolutionary conservation...
Sánchez Guardado L, Ferran J, Rodríguez Gallardo L, Puelles L, Hidalgo Sanchez M. Meis gene expression patterns in the developing chicken inner ear. J Comp Neurol. 2011;519:125-47 pubmed publisher
..As development proceeds, Meis1 and Meis2 expressions became restricted to the dorsomedial otic epithelium...
Sánchez Guardado L, Irimia M, Sánchez Arrones L, Burguera D, Rodríguez Gallardo L, Garcia Fernandez J, et al
. Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development. Dev Dyn. 2011;240:1475-92 pubmed publisher
..We show that the expression of both Meis genes begins at the gastrulation stage in the three embryonic layers, presenting highly dynamic patterns with overlapping as well as distinct expression domains throughout development. ..
Agoston Z, Li N, Haslinger A, Wizenmann A, Schulte D. Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. BMC Dev Biol. 2012;12:10 pubmed publisher
..and subsequent cooperation of the paired-type transcription factors Pax3, Pax7 and the TALE-homeodomain protein Meis2 in the tectal anlage...
Mercader N, Leonardo E, Azpiazu N, Serrano A, Morata G, Martinez C, et al
. Conserved regulation of proximodistal limb axis development by Meis1/Hth. Nature. 1999;402:425-9 pubmed
..We suggest that restriction of Meis1/Hth to proximal regions of the vertebrate and insect limb is essential to specify cell fates and differentiation patterns along the P-D axis of the limb. ..