interferon gamma


Gene Symbol: interferon gamma
Description: interferon gamma
Alias: interferon gamma, IFN-gamma, Interferon-gamma level, interferon-gama
Species: chicken
Products:     interferon gamma

Top Publications

  1. Kaiser P, Wain H, Rothwell L. Structure of the chicken interferon-gamma gene, and comparison to mammalian homologues. Gene. 1998;207:25-32 pubmed
    ..However, promoter sequence polymorphisms between different inbred lines of chickens have been identified, with possible links to disease resistance. ..
  2. Kim E, Hong Y, Lillehoj H. Genetic effects analysis of myeloid leukemia factor 2 and T cell receptor-beta on resistance to coccidiosis in chickens. Poult Sci. 2010;89:20-7 pubmed publisher
    ..These results suggest that the SNP in the MLF2 gene can be one of the markers to select coccidiosis resistance in chickens...
  3. Haq K, Wootton S, Barjesteh N, Golovan S, Bendall A, Sharif S. Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens. Can J Vet Res. 2015;79:1-7 pubmed
    ..Toutefois, l’administration de rAAAV exprimant des shRNA ciblant l’IFN-γ des oiseaux n’a pas semblé complètement abrogé la protection induite par le vaccin.(Traduit par Docteur Serge Messier). ..
  4. Weining K, Schultz U, Münster U, Kaspers B, Staeheli P. Biological properties of recombinant chicken interferon-gamma. Eur J Immunol. 1996;26:2440-7 pubmed
  5. Göbel T, Schneider K, Schaerer B, Mejri I, Puehler F, Weigend S, et al. IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species. J Immunol. 2003;171:1809-15 pubmed
  6. Deng Y, Cui H, Peng X, Fang J, Zuo Z, Wang K, et al. Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium. Biol Trace Elem Res. 2012;147:149-55 pubmed publisher
    ..Simultaneously, the changes in interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-?) and tumor necrosis factor-alpha (TNF-?) contents in the cecal tonsil were also quantified by enzyme-..
  7. Chrząstek K, Wieliczko A. The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-γ and IL-1β. Pol J Vet Sci. 2014;17:593-9 pubmed
    ..The data suggest that additional stimulus, e.g. the antigen, may be needed on the site of mucosal administration to activate systemic immune response. ..
  8. Digby M, Lowenthal J. Cloning and expression of the chicken interferon-gamma gene. J Interferon Cytokine Res. 1995;15:939-45 pubmed
    ..These findings show that the emergence of the two principal types of IFN predates the divergence of avians and mammals that occurred some 350 million years ago. ..
  9. Bhagat J, Ahmed K, Tyagi P, Saxena M, Saxena V. Effects of supplemental chromium on interferon-gamma (IFN-gamma) mRNA expression in response to Newcastle disease vaccine in broiler chicken. Res Vet Sci. 2008;85:46-51 pubmed
    ..Thus, the supplementation of chromium at appropriate dose might be helpful to enhance the IFN-gamma mRNA expression in response to NDV. ..

More Information


  1. Rauw F, Lambrecht B, van den Berg T. Pivotal role of ChIFNgamma in the pathogenesis and immunosuppression of infectious bursal disease. Avian Pathol. 2007;36:367-74 pubmed
    ..In conclusion, a ChIFNgamma dysregulation occurs in chickens infected with IBDV and the overproduction of ChIFNgamma by T lymphocytes plays a key role in the pathogenesis and immunosuppression induced by this virus. ..
  2. Karpala A, Morris K, Broadway M, McWaters P, O Neil T, Goossens K, et al. Molecular cloning, expression, and characterization of chicken IFN -lambda. J Interferon Cytokine Res. 2008;28:341-50 pubmed publisher
    ..Our results demonstrate that in the chicken, as in human, the antiviral activity demonstrated by ChIFN-lambda supports its inclusion in therapeutic strategies directed against viral infections. ..
  3. Ariaans M, van de Haar P, Hensen E, Vervelde L. Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes. Virology. 2009;385:68-73 pubmed publisher
    ..These results indicate that IBV acts as a polyclonal stimulus, inducing a rapid production of IFN-gamma even without previous exposure to the virus. ..
  4. Wang Y, Deng J, Xu S, Peng X, Zuo Z, Cui H, et al. Effects of zearalenone on IL-2, IL-6, and IFN-? mRNA levels in the splenic lymphocytes of chickens. ScientificWorldJournal. 2012;2012:567327 pubmed publisher
    ..05). These data suggest that ZEN has potent effects on the expression of chicken splenic lymphocytes cytokines at the mRNA level. ..
  5. Downing T, Lynn D, Connell S, Lloyd A, Bhuiyan A, Silva P, et al. Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics. 2009;61:303-14 pubmed publisher
  6. Shi F, Erf G. IFN-?, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens. J Invest Dermatol. 2012;132:642-9 pubmed publisher
    ..Taken together, SLV appears to be a Th1-polarized autoimmune disease, whereby IFN-? expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during early and active stages of SLV...
  7. Kim S, Cox C, Jenkins M, Fetterer R, Miska K, Dalloul R. Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor. Dev Comp Immunol. 2014;47:319-26 pubmed publisher
    ..during infection, bound to chicken macrophages via ChCD74p41 as a surface receptor. Together, this study provides conclusive evidence that both host and parasite MIF molecules bind to chicken macrophages via the surface receptor ChCD74. ..