interferon

Summary

Gene Symbol: interferon
Description: interferon
Alias: IFN-alpha, IFN-gamma, IFNA, IFNA1, IFNA2, IFNA6, interferon type A1/A2, IFN alpha, interferon alpha, interferon type A3
Species: chicken
Products:     interferon

Top Publications

  1. Sekellick M, Ferrandino A, Hopkins D, Marcus P. Chicken interferon gene: cloning, expression, and analysis. J Interferon Res. 1994;14:71-9 pubmed
    A gene encoding chicken interferon (ChIFN) was cloned from a cDNA library made from primary chick embryo cells that had been "aged" in vitro so as to produce copious amounts of IFN upon induction...
  2. Sick C, Schultz U, Staeheli P. A family of genes coding for two serologically distinct chicken interferons. J Biol Chem. 1996;271:7635-9 pubmed
    Southern blot analysis and screening of a genomic lambda phage library with the previously cloned chicken interferon (IFN) cDNA indicated that the chicken genome contains at least 10 IFN genes...
  3. Xia C, Liu J, Wu Z, Lin C, Wang M. The interferon-alpha genes from three chicken lines and its effects on H9N2 influenza viruses. Anim Biotechnol. 2004;15:77-88 pubmed
    The interferon-alpha genes from three chicken lines were cloned by a direct PCR technique, and the effects of recombinant protein expressed in a prokaryotic system on highly pathogenic H9N2 influenza viruses were investigated...
  4. Balenović M, Savic V, Ekert Kabalin A, Jurinović L, Ragland W. Abundance of IFN-? and IFN-? gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV. Acta Vet Hung. 2011;59:141-8 pubmed publisher
    ..The results show that cells stimulated to produce IFN-? and IFN-? enter the circulating blood but those stimulated to produce IL-2 do not, or in very low number, and the IFN responses to both vaccines are the same. ..
  5. Schusser B, Reuter A, von der Malsburg A, Penski N, Weigend S, Kaspers B, et al. Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus. J Virol. 2011;85:8307-15 pubmed publisher
    The type I interferon (IFN) system plays an important role in antiviral defense against influenza A viruses (FLUAV), which are natural chicken pathogens...
  6. Buttigieg K, Laidlaw S, Ross C, Davies M, Goodbourn S, Skinner M. Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response. J Virol. 2013;87:5028-40 pubmed publisher
    Viruses must be able to resist host innate responses, especially the type I interferon (IFN) response. They do so by preventing the induction or activity of IFN and/or by resisting the antiviral effectors that it induces...
  7. Liu F, Campagna M, Qi Y, Zhao X, Guo F, Xu C, et al. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. PLoS Pathog. 2013;9:e1003613 pubmed publisher
    ..Moreover, IFN-? treatment also induced a delayed response that appeared to accelerate the decay of cccDNA. Our studies have thus shed light on the molecular mechanism by which IFN-? noncytolytically controls hepadnavirus infection...

Detail Information

Publications7

  1. Sekellick M, Ferrandino A, Hopkins D, Marcus P. Chicken interferon gene: cloning, expression, and analysis. J Interferon Res. 1994;14:71-9 pubmed
    A gene encoding chicken interferon (ChIFN) was cloned from a cDNA library made from primary chick embryo cells that had been "aged" in vitro so as to produce copious amounts of IFN upon induction...
  2. Sick C, Schultz U, Staeheli P. A family of genes coding for two serologically distinct chicken interferons. J Biol Chem. 1996;271:7635-9 pubmed
    Southern blot analysis and screening of a genomic lambda phage library with the previously cloned chicken interferon (IFN) cDNA indicated that the chicken genome contains at least 10 IFN genes...
  3. Xia C, Liu J, Wu Z, Lin C, Wang M. The interferon-alpha genes from three chicken lines and its effects on H9N2 influenza viruses. Anim Biotechnol. 2004;15:77-88 pubmed
    The interferon-alpha genes from three chicken lines were cloned by a direct PCR technique, and the effects of recombinant protein expressed in a prokaryotic system on highly pathogenic H9N2 influenza viruses were investigated...
  4. Balenović M, Savic V, Ekert Kabalin A, Jurinović L, Ragland W. Abundance of IFN-? and IFN-? gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV. Acta Vet Hung. 2011;59:141-8 pubmed publisher
    ..The results show that cells stimulated to produce IFN-? and IFN-? enter the circulating blood but those stimulated to produce IL-2 do not, or in very low number, and the IFN responses to both vaccines are the same. ..
  5. Schusser B, Reuter A, von der Malsburg A, Penski N, Weigend S, Kaspers B, et al. Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus. J Virol. 2011;85:8307-15 pubmed publisher
    The type I interferon (IFN) system plays an important role in antiviral defense against influenza A viruses (FLUAV), which are natural chicken pathogens...
  6. Buttigieg K, Laidlaw S, Ross C, Davies M, Goodbourn S, Skinner M. Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response. J Virol. 2013;87:5028-40 pubmed publisher
    Viruses must be able to resist host innate responses, especially the type I interferon (IFN) response. They do so by preventing the induction or activity of IFN and/or by resisting the antiviral effectors that it induces...
  7. Liu F, Campagna M, Qi Y, Zhao X, Guo F, Xu C, et al. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. PLoS Pathog. 2013;9:e1003613 pubmed publisher
    ..Moreover, IFN-? treatment also induced a delayed response that appeared to accelerate the decay of cccDNA. Our studies have thus shed light on the molecular mechanism by which IFN-? noncytolytically controls hepadnavirus infection...