insulin like growth factor I receptor


Gene Symbol: insulin like growth factor I receptor
Description: insulin like growth factor 1 receptor
Alias: IGF-1R, insulin-like growth factor 1 receptor, IGF-I receptor, insulin-like growth factor I receptor, insulin-like growth factor receptor tyrosine kinase, type 1 IGF receptor, tyrosine kinase
Species: chicken

Top Publications

  1. Armstrong D, Hogg C. The expression of a putative insulin-like growth factor-I receptor gene in the liver of the developing chick. J Mol Endocrinol. 1992;8:193-201 pubmed
    ..A major IGF-I receptor RNA transcript (11 kb) was observed in blots from 1-week-old livers, less abundant transcripts were also observed ranging in size from 8 to 9 kb.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  2. Scavo L, Serrano J, Roth J, De Pablo F. Genes for the insulin receptor and the insulin-like growth factor I receptor are expressed in the chicken embryo blastoderm and throughout organogenesis. Biochem Biophys Res Commun. 1991;176:1393-401 pubmed
    ..We report two chicken sequences that, by comparison with known tyrosine kinases, appear to correspond to the tyrosine kinase domain of the insulin receptor homologue (CTK-1) and the IGF-I receptor homologue (CTK-2)...
  3. Matsumura Y, Domeki M, Sugahara K, Kubo T, Roberts C, LeRoith D, et al. Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens. Biosci Biotechnol Biochem. 1996;60:979-82 pubmed
    ..The mRNA levels were reduced to the control level by refeeding of the starved chickens for 24h. These data suggest a tissue- and development-specific response of chicken IGF-I receptor gene expression to nutritional status. ..
  4. Holzenberger M, Lapointe F, Leibovici M, Lievre C. The avian IGF type 1 receptor: cDNA analysis and in situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system. Brain Res Dev Brain Res. 1996;97:76-87 pubmed
    Insulin-like growth factor type 1 receptor (IGF-1R) is a tyrosine kinase with a key role in development. The primary structure of IGF-1R is known for mammalian species, but not for birds...
  5. Jin S, Chen S, Li H, Lu Y, Xu G, Yang N. Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens. Mol Biol Rep. 2014;41:3973-9 pubmed publisher
    ..05). Therefore, it was concluded that the identified SNPs and analyzed haplotypes in this study might be useful for broiler breeding programs. ..
  6. Koritschoner N, Bartunek P, Knespel S, Blendinger G, Zenke M. The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation. Oncogene. 1999;18:5904-14 pubmed
    ..Here we conducted a comprehensive survey of tyrosine kinase gene expression in primary erythroid progenitor cells from bone marrow by employing a PCR-based strategy that ..
  7. Lei M, Peng X, Zhou M, Luo C, Nie Q, Zhang X. Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits. BMC Genet. 2008;9:70 pubmed publisher
    ..Several SNPs associated with chicken early growth traits and carcass traits were identified in the IGF1R gene by genetic diversity, linkage disequilibrium, and association analyses in the present study. ..
  8. Penha A, Schaeffel F, Feldkaemper M. Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus. Mol Vis. 2011;17:1436-48 pubmed
    ..The differential regulation of IR and IGF-1R in the RPE, choroid, and fibrous sclera is consistent with their involvement in a signaling cascade for emmetropization...
  9. Basu S, Rajakaruna S, Menko A. Insulin-like growth factor receptor-1 and nuclear factor ?B are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2012;287:8384-97 pubmed publisher
    ..These results provided the first evidence that the IGF-1R/NF?B cell survival signal is a crucial regulator of the level of caspase-3 activation for its non-apoptotic function in signaling cell differentiation. ..

More Information


  1. Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges Labouesse E, Menko A. ?6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014;289:3842-55 pubmed publisher
    ..We conclude that ?6 integrin is an essential upstream regulator of the IGF-1R survival pathway that regulates the activity level of caspase-3 for it to signal differentiation initiation of lens epithelial cells. ..