Gene Symbol: ID2
Description: inhibitor of DNA binding 2, HLH protein
Alias: DNA-binding protein inhibitor ID-2, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, transcriptional regulator Id2
Species: chicken
Products:     ID2

Top Publications

  1. Martinsen B, Bronner Fraser M. Neural crest specification regulated by the helix-loop-helix repressor Id2. Science. 1998;281:988-91 pubmed
    ..The chick homolog of the helix-loop-helix transcriptional regulator Id2 is expressed in cranial but not trunk neural folds and subsequently in some migrating cranial neural ..
  2. Martinsen B, Frasier A, Baker C, Lohr J. Cardiac neural crest ablation alters Id2 gene expression in the developing heart. Dev Biol. 2004;272:176-90 pubmed
    ..We have evaluated the expression of Id2 in the developing chick heart and found expression in the cardiac neural crest, secondary heart field, outflow ..
  3. Bai G, Sheng N, Xie Z, Bian W, Yokota Y, Benezra R, et al. Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev Cell. 2007;13:283-97 pubmed
    ..Overexpression of Id2 in the chick hindbrain upregulates Hes1 expression and inhibits proneural gene expression and neuronal ..
  4. Lorda Diez C, Torre PĂ©rez N, Garcia Porrero J, Hurle J, Montero J. Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits. Int J Dev Biol. 2009;53:1495-502 pubmed publisher
    Here we report the pattern of expression of inhibitor of DNA binding/differentiation factor 2 (Id2) in the developing chicken limb...
  5. Krishan K, McKinnell I, Patel K, Dhoot G. Dynamic Id2 expression in the medial and lateral domains of avian dermamyotome. Dev Dyn. 2005;234:363-70 pubmed
    b>Id2 cDNA was isolated from a subtractive screen of stage-12 quail caudal somites...
  6. Kamaid A, Neves J, Giraldez F. Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1. J Neurosci. 2010;30:11426-34 pubmed publisher
    ..The differential regulation of Ids in time and space may underlie the multiple functions of Bmp signaling during sensory organ development. ..
  7. Lorda Diez C, Montero J, Choe S, Garcia Porrero J, Hurle J. Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res. 2014;29:735-48 pubmed publisher
    ..Gene-silencing experiments indicate that Id2 is one of the factors limiting the profibrogenic influence of BMPs...