HRAS

Summary

Gene Symbol: HRAS
Description: HRas proto-oncogene, GTPase
Alias: H-RAS, HRAS1, GTPase HRas, H-Ras-1, Harvey rat sarcoma viral oncogene homolog, c-H-ras, p21ras, transforming protein p21, v-Ha-ras Harvey rat sarcoma viral oncogene homolog, v-Ha-ras Harvey rat sarcoma viral oncogene-like protein
Species: chicken
Products:     HRAS

Top Publications

  1. Westaway D, Papkoff J, Moscovici C, Varmus H. Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript. EMBO J. 1986;5:301-9 pubmed
    ..Little or no increase in c-Ha-ras RNA or protein was observed in other nephroblastomas. ..
  2. Imamura Y, Oda A, Katahira T, Bundo K, Pike K, Ratcliffe M, et al. BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. J Biol Chem. 2009;284:9804-13 pubmed publisher
    ..These results indicate that BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation. ..
  3. Pecenka V, Pajer P, Karafiat V, Kasparová P, Dudlová J, Dvorak M. HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2. J Virol. 2017;91: pubmed publisher
    ..86% of these tumors, MAV-2 provirus had integrated into one of four gene loci: HRAS, EGFR, MET, and RON Insertionally mutated genes correlated with tumor type: HRAS ..