Gene Symbol: HIST2H4B
Description: histone cluster 2, H4b
Alias: H4-I, H4-II, H4-III, H4-IV, H4-V, H4-VI, H4-VII, H4/o, HIST1H47, histone H4, H4 (aa 1-103), histone 2, H4b, histone H4 (aa 1-103), histone H4-VII, histone cluster 1, histone class H4, member 7 (similar to human histone cluster 1, class H4 genes)
Species: chicken
Products:     HIST2H4B

Top Publications

  1. Nakayama T, Takechi S, Ohshige T, Kondo K, Yamamoto K. Nucleotide sequences of two members of the chicken H4 histone-encoding gene family. Gene. 1991;108:311-2 pubmed
  2. Arents G, Burlingame R, Wang B, Love W, Moudrianakis E. The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix. Proc Natl Acad Sci U S A. 1991;88:10148-52 pubmed
    ..The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold. ..
  3. Sugarman B, Dodgson J, Engel J. Genomic organization, DNA sequence, and expression of chicken embryonic histone genes. J Biol Chem. 1983;258:9005-16 pubmed
    ..e. from at least 4 days postfertilization up to hatching, about 20-21 days postfertilization) and appear not to be associated with any particular tissue type. ..
  4. Takami Y, Higashio M, Fukuoka T, Takechi S, Nakayama T. Organization of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences. DNA Res. 1996;3:95-9 pubmed
    ..Results of our sequence analyses, together with those reported previously, generated a set of the core histone amino acid sequences as follows: three H2A variants, four H2B variants, two H3 variants and an H4 protein. ..
  5. Herrera J, Schiltz R, Bustin M. The accessibility of histone H3 tails in chromatin modulates their acetylation by P300/CBP-associated factor. J Biol Chem. 2000;275:12994-9 pubmed
  6. Sanematsu F, Takami Y, Barman H, Fukagawa T, Ono T, Shibahara K, et al. Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells. J Biol Chem. 2006;281:13817-27 pubmed
  7. Wang S, Robins A, D ANDREA R, Wells J. Inverted duplication of histone genes in chicken and disposition of regulatory sequences. Nucleic Acids Res. 1985;13:1369-87 pubmed
  8. Ikura T, Ogryzko V, Grigoriev M, Groisman R, Wang J, Horikoshi M, et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell. 2000;102:463-73 pubmed
    ..These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis. ..
  9. Harp J, Hanson B, Timm D, Bunick G. Asymmetries in the nucleosome core particle at 2.5 A resolution. Acta Crystallogr D Biol Crystallogr. 2000;56:1513-34 pubmed
    ..An analysis is made of the asymmetries by comparisons both within the nucleosome core particle and to the structure of the histone octamer core of the nucleosome. ..

More Information


  1. Pineau P, Henry M, Susp ne R, Marchio A, Dettai A, Debruyne R, et al. A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species. Mol Biol Evol. 2005;22:582-8 pubmed publisher
    ..The histone H4 gene family comprises a small number of genes considered among the most conserved genes in living organisms...
  2. Sampath V, Liu B, Tafrov S, Srinivasan M, Rieger R, Chen E, et al. Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae. J Biol Chem. 2013;288:21506-13 pubmed publisher
    ..Whereas Hpa2 acetylated histones H3 and H4 (at H3 Lys-14, H4 Lys-5, and H4 Lys-12), Hpa3 acetylated only histone H4 (at Lys-8). Additionally, Hpa2, but not Hpa3, acetylated certain small basic proteins...