Gene Symbol: HIST1H2A4
Description: histone cluster 1, H2A, IV
Alias: HIST2H2AC, histone H2A-IV, histone cluster 1, H2A, IV (similar to human histone cluster 2, class H2A, member C), histone cluster 2, H2ac
Nickel B, Allis C, Davie J. Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin. Biochemistry. 1989;28:958-63 pubmed
..These observations are consistent with the hypothesis that ubiquitinated histones have a role maintaining the structure of transcriptionally active chromatin...
Laine B, Kmiecik D, Sautiere P, Biserte G. Primary structure of chicken erythrocyte histone H2A. Biochimie. 1978;60:147-50 pubmed
Arents G, Burlingame R, Wang B, Love W, Moudrianakis E. The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix. Proc Natl Acad Sci U S A. 1991;88:10148-52 pubmed
..The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold. ..
Wang S, Robins A, D ANDREA R, Wells J. Inverted duplication of histone genes in chicken and disposition of regulatory sequences. Nucleic Acids Res. 1985;13:1369-87 pubmed
Li W, Nagaraja S, Delcuve G, Hendzel M, Davie J. Effects of histone acetylation, ubiquitination and variants on nucleosome stability. Biochem J. 1993;296 ( Pt 3):737-44 pubmed
..The elevated lability of the H2A-H2B dimer may facilitate processes such as the exchange of these dimers with newly synthesized histones, the elongation process of transcription and transcription factor binding. ..
Takami Y, Higashio M, Fukuoka T, Takechi S, Nakayama T. Organization of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences. DNA Res. 1996;3:95-9 pubmed
..Results of our sequence analyses, together with those reported previously, generated a set of the core histone amino acid sequences as follows: three H2A variants, four H2B variants, two H3 variants and an H4 protein. ..
Herrera J, Schiltz R, Bustin M. The accessibility of histone H3 tails in chromatin modulates their acetylation by P300/CBP-associated factor. J Biol Chem. 2000;275:12994-9 pubmed
Sampath V, Liu B, Tafrov S, Srinivasan M, Rieger R, Chen E, et al
. Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae. J Biol Chem. 2013;288:21506-13 pubmed publisher
..These results suggest that Hpa2 and Hpa3 are similar but distinct acetyltransferases that might have overlapping roles with other known acetyltransferases in vivo in acetylating histones and other small proteins. ..
Robins A, Wang S, Smith T, Wells J. A unique element resembling a processed pseudogene. J Biol Chem. 1986;261:18-20 pubmed
..The element was detected in DNA from different chickens and in peafowl, but not in quail, pheasant, or turkey. ..