HIRA

Summary

Gene Symbol: HIRA
Description: histone cell cycle regulator
Alias: protein HIRA, HIR histone cell cycle regulation defective homolog A, TUP1-like enhancer of split protein 1, cHIRA
Species: chicken

Top Publications

  1. Roberts C, Daw S, Halford S, Scambler P. Cloning and developmental expression analysis of chick Hira (Chira), a candidate gene for DiGeorge syndrome. Hum Mol Genet. 1997;6:237-45 pubmed
    ..The TUPLE1/HIRA gene is related to WD40 domain transcriptional regulators and maps within the DiGeorge critical region...
  2. Ahmad A, Takami Y, Nakayama T. WD dipeptide motifs and LXXLL motif of chicken HIRA are necessary for transcription repression and the latter motif is essential for interaction with histone deacetylase-2 in vivo. Biochem Biophys Res Commun. 2003;312:1266-72 pubmed
    We previously reported not only that chicken HIRA, a homolog of Saccharomyces cerevisiae transcriptional corepressors Hir1p and Hir2p, possesses seven WD dipeptide motifs and a LXXLL motif in its N-terminal half and C-terminal half, ..
  3. Ahmad A, Takami Y, Nakayama T. WD dipeptide motifs and LXXLL motif of chicken HIRA are essential for interactions with the p48 subunit of chromatin assembly factor-1 and histone deacetylase-2 in vitro and in vivo. Gene. 2004;342:125-36 pubmed
    We cloned cDNA encoding chicken HIRA, a homolog of Saccharomyces cerevisiae transcriptional corepressors Hir1p and Hir2p, possessing seven WD dipeptide motifs and a LXXLL motif in its N-terminal and C-terminal regions, respectively...
  4. Ahmad A, Kikuchi H, Takami Y, Nakayama T. Different roles of N-terminal and C-terminal halves of HIRA in transcription regulation of cell cycle-related genes that contribute to control of vertebrate cell growth. J Biol Chem. 2005;280:32090-100 pubmed
    We reported previously that chicken HIRA, a homolog of Saccharomyces cerevisiae transcriptional co-repressors Hir1p and Hir2p, possesses seven WD dipeptide motifs and an LXXLL motif in its N-terminal and C-terminal halves, respectively, ..
  5. Sanematsu F, Takami Y, Barman H, Fukagawa T, Ono T, Shibahara K, et al. Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells. J Biol Chem. 2006;281:13817-27 pubmed
    ..to the N-terminal core domain (amino acids 1-155) that is a binding platform for histones H3/H4, CAF-1p60, and HIRA, whereas Asf1 mutant proteins, abolishing binding abilities with both p60 and HIRA, exhibit no effect on viability...