Gene Symbol: HBZ
Description: hemoglobin subunit zeta
Alias: HBAP, hemoglobin subunit pi, embryonic alpha-globin pi-prime, hemoglobin alpha, subunit pi, hemoglobin pi chain, hemoglobin pi' chain, hemoglobin, zeta, pi-globin
Chapman B, Tobin A, Hood L. Complete amino acid sequences of the major early embryonic alpha-like globins of the chicken. J Biol Chem. 1980;255:9051-9 pubmed
..We discuss specific amino acid substitutions in functional positions as possible mediators of the reduced Bohr effect and elevated oxygen affinity, which are characteristic of early embryonic hemoglobins. ..
Flint J, Tufarelli C, Peden J, Clark K, Daniels R, Hardison R, et al
. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet. 2001;10:371-82 pubmed
..In addition to delimiting the alpha globin chromosomal domain, this study has enabled us to develop a more sensitive and accurate routine for identifying regulatory elements in the human genome. ..
Razin S, Rynditch A, Borunova V, Ioudinkova E, Smalko V, Scherrer K. The 33 kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix. J Cell Biochem. 2004;92:445-57 pubmed
..They may take part in the dynamic nuclear architecture when productively processed, or turn over slowly when globins are not synthesised...
Ioudinkova E, Ulianov S, Bunina D, Iarovaia O, Gavrilov A, Razin S. The inactivation of the ? gene in chicken erythroblasts of adult lineage is not mediated by packaging of the embryonic part of the ?-globin gene domain into a repressive heterochromatin-like structure. Epigenetics. 2011;6:1481-8 pubmed publisher
..This conclusion is supported by the demonstration that in chicken erythroblasts of adult lineage, the embryonal and adult segments of the ?-globin gene domain show similar elevated sensitivities to DNase I...
Engel J, Rusling D, McCune K, Dodgson J. Unusual structure of the chicken embryonic alpha-globin gene, pi'. Proc Natl Acad Sci U S A. 1983;80:1392-6 pubmed
..This conclusion is drawn from the observation that the two chromosomal alleles of embryonic alpha-globins (represented by recombinant bacteriophage lambda CaG5 and lambda CaG7) both encode pi'. ..
Iudinkova E, Bunina D, Ul ianov S, Gavrilov A, Razin S. [Patterns of the histone modifications across the chicken alpha-globin genes domain]. Mol Biol (Mosk). 2011;45:662-7 pubmed