Gene Symbol: HBM
Description: hemoglobin subunit mu
Alias: HBA2, HBAD, hemoglobin subunit alpha-D, adult alpha D globin, alpha-D-globin, hemoglobin alpha, subunit D, hemoglobin alpha-D chain, hemoglobin, alpha 2
Species: chicken

Top Publications

  1. Dodgson J, Engel J. The nucleotide sequence of the adult chicken alpha-globin genes. J Biol Chem. 1983;258:4623-9 pubmed
    ..Extensive flanking sequences are reported for both genes. The chromosomal sequences of the two genes are compared to each other and to sequenced mammalian alpha-globin genes. ..
  2. Lewis W, Lee J, Dodgson J. Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region. Nucleic Acids Res. 1991;19:5321-9 pubmed
  3. Chapman B, Hood L, Tobin A. Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains. J Biol Chem. 1982;257:651-8 pubmed
    ..with the nucleotide sequence of the alpha D globin gene suggests that a single gene encodes both the embryonic and adult alpha D globin polypeptides. We discuss the structure, possible function, and evolution of the HbM globin chains.
  4. Takei H, Ota Y, Wu K, Kiyohara T, Matsuda G. Amino acid sequence of the alpha chain of chicken AI hemoglobin. J Biochem. 1975;77:1345-7 pubmed
    ..An unexpectedly large difference of 65 amino acids was found between these two chains. ..
  5. Dodgson J, McCune K, Rusling D, Krust A, Engel J. Adult chicken alpha-globin genes alpha A and alpha D: no anemic shock alpha-globin exists in domestic chickens. Proc Natl Acad Sci U S A. 1981;78:5998-6002 pubmed
    ..Therefore, we suggest that the alpha S-type sequence corresponds to the true alpha A-globin species. ..
  6. Razin S, Rynditch A, Borunova V, Ioudinkova E, Smalko V, Scherrer K. The 33 kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix. J Cell Biochem. 2004;92:445-57 pubmed
    ..They may take part in the dynamic nuclear architecture when productively processed, or turn over slowly when globins are not synthesised...
  7. Knapp J, Oliveira M, Xie Q, Ernst S, Riggs A, Hackert M. The structural and functional analysis of the hemoglobin D component from chicken. J Biol Chem. 1999;274:6411-20 pubmed
    ..This hydrophobic patch is a promising candidate for a tetramer-tetramer interface that could regulate oxygen binding via the distal histidine. ..
  8. Flint J, Tufarelli C, Peden J, Clark K, Daniels R, Hardison R, et al. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet. 2001;10:371-82 pubmed
    ..In addition to delimiting the alpha globin chromosomal domain, this study has enabled us to develop a more sensitive and accurate routine for identifying regulatory elements in the human genome. ..
  9. Gavrilov A, Razin S. Study of spatial organization of chicken alpha-globin gene domain by 3C technique. Biochemistry (Mosc). 2008;73:1192-9 pubmed
    ..We suppose that such interaction is necessary to provide for the active transcription status of the chicken alpha-globin gene domains in erythroid cells. ..

More Information


  1. Rana M, Riggs A. Indefinite noncooperative self-association of chicken deoxy hemoglobin D. Proteins. 2011;79:1499-512 pubmed publisher
    ..Residue glutamate 138 has previously been proposed to influence intertetramer interactions. Our results with recombinant Hb D show that Glu138 plays no role in deoxy Hb D intertetramer interactions. ..