Gene Symbol: HBA1
Description: hemoglobin subunit alpha 1
Alias: HBAA, alpha-A-globin, hemoglobin subunit alpha-A, adult alpha A globin, alpha-A globin, hemoglobin alpha, subunit A, hemoglobin alpha, subunit?A, hemoglobin alpha-A chain, hemoglobin, alpha 1
Species: chicken
Products:     HBA1

Top Publications

  1. Cummings I, Liu A, Salser W. Identification of a new chicken alpha-globin structural gene by complementary DNA cloning. Nature. 1978;276:418-9 pubmed
  2. Knochel W, Wittig B, Wittig S, John M, Grundmann U, Oberthür W, et al. No evidence for 'stress' alpha-globin genes in chicken. Nature. 1982;295:710-2 pubmed
  3. Lewis W, Lee J, Dodgson J. Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region. Nucleic Acids Res. 1991;19:5321-9 pubmed
  4. Borunova V, Iarovaia O, Vassetzky Y, Razin S. The upstream area of the chicken alpha-globin gene domain is transcribed in both directions in the same cells. FEBS Lett. 2005;579:4746-50 pubmed
  5. Liu A, Salser W. Complete nucleotide sequence of a chicken alpha-globin cDNA. Gene. 1981;13:409-15 pubmed
    ..The possibility that this alpha-globin might represent a stress globin is considered. ..
  6. Dodgson J, McCune K, Rusling D, Krust A, Engel J. Adult chicken alpha-globin genes alpha A and alpha D: no anemic shock alpha-globin exists in domestic chickens. Proc Natl Acad Sci U S A. 1981;78:5998-6002 pubmed
    ..Therefore, we suggest that the alpha S-type sequence corresponds to the true alpha A-globin species. ..
  7. Richards R, Wells J. Chicken globin genes. Nucleotide sequence of cDNA clones coding for the alpha-globin expressed during hemolytic anemia. J Biol Chem. 1980;255:9306-11 pubmed
  8. Dodgson J, Engel J. The nucleotide sequence of the adult chicken alpha-globin genes. J Biol Chem. 1983;258:4623-9 pubmed
    ..Extensive flanking sequences are reported for both genes. The chromosomal sequences of the two genes are compared to each other and to sequenced mammalian alpha-globin genes. ..
  9. Flint J, Tufarelli C, Peden J, Clark K, Daniels R, Hardison R, et al. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet. 2001;10:371-82 pubmed
    ..In addition to delimiting the alpha globin chromosomal domain, this study has enabled us to develop a more sensitive and accurate routine for identifying regulatory elements in the human genome. ..

More Information


  1. Razin S, Rynditch A, Borunova V, Ioudinkova E, Smalko V, Scherrer K. The 33 kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix. J Cell Biochem. 2004;92:445-57 pubmed
    ..They may take part in the dynamic nuclear architecture when productively processed, or turn over slowly when globins are not synthesised...
  2. Matsuda G, Takei H, Wu K, Shiozawa T, Ota Y. Sequence studies on the tryptic peptides and the chymotryptic peptides from the polypeptide chain of aII component of the chicken hemoglobin. Biochemical studies on hemoglobins and myoglobins. 8. Int J Pept Protein Res. 1972;4:291-302 pubmed
  3. Deacon N, Shine J, Naora H. Complete nucleotide sequence of a cloned chicken alpha-globin cDNA. Nucleic Acids Res. 1980;8:1187-99 pubmed
    ..One of the alpha-type clones (pCG alpha-8) was fully sequenced and found to code for neither alpha A- nor alpha D-globin. Partial sequencing of the other alpha-cDNA clones indicates that they are all of the same type. ..
  4. Gavrilov A, Razin S. Study of spatial organization of chicken alpha-globin gene domain by 3C technique. Biochemistry (Mosc). 2008;73:1192-9 pubmed
    ..We suppose that such interaction is necessary to provide for the active transcription status of the chicken alpha-globin gene domains in erythroid cells. ..
  5. Klochkov D, Gavrilov A, Vassetzky Y, Razin S. Early replication timing of the chicken alpha-globin gene domain correlates with its open chromatin state in cells of different lineages. Genomics. 2009;93:481-6 pubmed publisher
  6. Rincón Arano H, Guerrero G, Valdes Quezada C, Recillas Targa F. Chicken alpha-globin switching depends on autonomous silencing of the embryonic pi globin gene by epigenetics mechanisms. J Cell Biochem. 2009;108:675-87 pubmed publisher
    ..We propose that epigenetic mechanisms are necessary for in vivo chicken alpha-globin gene switching through differential gene silencing of the embryonic alpha-globin gene in order to allow proper activation of adult alpha-globin genes...
  7. Labas V, Grasseau I, Cahier K, Gargaros A, Harichaux G, Teixeira Gomes A, et al. Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen. J Proteomics. 2015;112:313-35 pubmed publisher
  8. García González E, Recillas Targa F. A regulatory element affects the activity and chromatin structure of the chicken α-globin 3' enhancer. Biochim Biophys Acta. 2014;1839:1233-41 pubmed publisher
    ..Our results suggest that the UEE activity contributes to the positioning of a nucleosome that is necessary for the α-globin 3' enhancer activation. ..