FASN

Summary

Gene Symbol: FASN
Description: fatty acid synthase
Alias: fatty acid synthase, thioesterase
Species: chicken
Products:     FASN

Top Publications

  1. Holzer K, Liu W, Hammes G. Molecular cloning and sequencing of chicken liver fatty acid synthase cDNA. Proc Natl Acad Sci U S A. 1989;86:4387-91 pubmed
    The complete amino acid sequence of chicken liver fatty acid synthase [acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, and thioester-hydrolyzing), EC 2.3.1...
  2. Chang S, Hammes G. Amino acid sequences of pyridoxal 5'-phosphate binding sites and fluorescence resonance energy transfer in chicken liver fatty acid synthase. Biochemistry. 1989;28:3781-8 pubmed
    The amino acid sequences associated with pyridoxal 5'-phosphate binding sites in chicken liver fatty acid synthase have been determined: a site whose modification causes selective inhibition of the enoyl reductase activity and a site (..
  3. Rosebrough R, Russell B, Richards M. Further studies on short-term adaptations in the expression of lipogenic genes in broilers. Comp Biochem Physiol A Mol Integr Physiol. 2011;159:1-6 pubmed publisher
    ..In addition, ME, AAT, ICD, fatty acid synthase (FAS), and acetyl coenzyme carboxylase (ACC) gene expression rates were determined...
  4. Huang W, Stoops J, Wakil S. Complete amino acid sequence of chicken liver acyl carrier protein derived from the fatty acid synthase. Arch Biochem Biophys. 1989;270:92-8 pubmed
    The acyl carrier protein domain of the chicken liver fatty acid synthase has been isolated after tryptic treatment of the synthase...
  5. Yuan Z, Liu W, Hammes G. Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA. Proc Natl Acad Sci U S A. 1988;85:6328-31 pubmed
    The cDNA corresponding to 4.18 kilobases (kb) of the mRNA of chicken liver fatty acid synthase has been cloned and sequenced. The cDNA corresponds to the 3' end of the mRNA and consists of a 1.87-kb noncoding tail and a 2...
  6. Demeure O, Duby C, Desert C, Assaf S, Hazard D, Guillou H, et al. Liver X receptor alpha regulates fatty acid synthase expression in chicken. Poult Sci. 2009;88:2628-35 pubmed publisher
    ..Here we show that fatty acid synthase and the expression of other lipogenic genes (sterol regulatory element binding protein 1 and steroyl ..
  7. Huang J, Zhang Y, Zhou Y, Wan X, Zhang J. Effects of epigallocatechin gallate on lipid metabolism and its underlying molecular mechanism in broiler chickens. J Anim Physiol Anim Nutr (Berl). 2015;99:719-27 pubmed publisher
    ..Simultaneously, the activities of hepatic fatty acid synthesis enzymes (fatty acid synthase and acetyl CoA carboxylase) were significantly decreased, and the activity of carnitine palmitoyl ..
  8. Chirala S, Kasturi R, Pazirandeh M, Stolow D, Huang W, Wakil S. A novel cDNA extension procedure. Isolation of chicken fatty acid synthase cDNA clones. J Biol Chem. 1989;264:3750-7 pubmed
    ..We have successfully used this method to isolate 4.6 kilobase pairs of chicken fatty acid synthase cDNA clones, starting from the fragment of a genomic clone coding for the untranslated region of the fatty ..
  9. Yang C, Huang W, Chirala S, Wakil S. Complete amino acid sequence of the thioesterase domain of chicken liver fatty acid synthase. Biochemistry. 1988;27:7773-7 pubmed
    The complete amino acid sequence of thioesterase domain of chicken liver fatty acid synthase has been determined by sequencing peptides produced by trypsin, Staphylococcus aureus V8 protease, and cyanogen bromide cleavage...

More Information

Publications13

  1. Kasturi R, Chirala S, Pazirandeh M, Wakil S. Characterization of a genomic and cDNA clone coding for the thioesterase domain and 3' noncoding region of the chicken liver fatty acid synthase gene. Biochemistry. 1988;27:7778-85 pubmed
    The fatty acid synthase (FAS) of animal tissue is a dimer of two identical subunits, each with a Mr of 260,000...
  2. Dridi S, Ververken C, Hillgartner F, Arckens L, Lutgarde A, Van der Gucht E, et al. FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Am J Physiol Regul Integr Comp Physiol. 2006;291:R138-47 pubmed
    Cerulenin, a natural fatty acid synthase (FAS) inhibitor, and its synthetic analog C75 are hypothesized to alter the metabolism of neurons in the hypothalamus that regulate ingestive behavior to cause a profound decrease of food intake ..
  3. Cui H, Zheng M, Liu R, Zhao G, Chen J, Wen J. Liver dominant expression of fatty acid synthase (FAS) gene in two chicken breeds during intramuscular-fat development. Mol Biol Rep. 2012;39:3479-84 pubmed publisher
    b>Fatty acid synthase (FAS) is a key enzyme of lipogenesis...
  4. Huang W, Chirala S, Wakil S. Amino-terminal blocking group and sequence of the animal fatty acid synthase. Arch Biochem Biophys. 1994;314:45-9 pubmed
    We have cloned and sequenced the cDNA encoding the chicken fatty acid synthase. Based on the nucleotide-derived amino acid sequence of the chicken synthase, the N-terminal sequences are highly conserved among animal species, suggesting ..