Genomes and Genes
Gene Symbol: FASN
Description: fatty acid synthase
Alias: fatty acid synthase, thioesterase
- Kasturi R, Chirala S, Pazirandeh M, Wakil S. Characterization of a genomic and cDNA clone coding for the thioesterase domain and 3' noncoding region of the chicken liver fatty acid synthase gene. Biochemistry. 1988;27:7778-85 pubmedThe fatty acid synthase (FAS) of animal tissue is a dimer of two identical subunits, each with a Mr of 260,000...
- Dridi S, Ververken C, Hillgartner F, Arckens L, Lutgarde A, Van der Gucht E, et al. FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Am J Physiol Regul Integr Comp Physiol. 2006;291:R138-47 pubmedCerulenin, a natural fatty acid synthase (FAS) inhibitor, and its synthetic analog C75 are hypothesized to alter the metabolism of neurons in the hypothalamus that regulate ingestive behavior to cause a profound decrease of food intake ..
- Cui H, Zheng M, Liu R, Zhao G, Chen J, Wen J. Liver dominant expression of fatty acid synthase (FAS) gene in two chicken breeds during intramuscular-fat development. Mol Biol Rep. 2012;39:3479-84 pubmed publisherb>Fatty acid synthase (FAS) is a key enzyme of lipogenesis...
- Huang W, Chirala S, Wakil S. Amino-terminal blocking group and sequence of the animal fatty acid synthase. Arch Biochem Biophys. 1994;314:45-9 pubmedWe have cloned and sequenced the cDNA encoding the chicken fatty acid synthase. Based on the nucleotide-derived amino acid sequence of the chicken synthase, the N-terminal sequences are highly conserved among animal species, suggesting ..