Gene Symbol: FANCC
Description: Fanconi anemia complementation group C
Alias: Fanconi anemia group C protein, Fanconi anemia, complementation group C protein
Kitao H, Yamamoto K, Matsushita N, Ohzeki M, Ishiai M, Takata M. Functional interplay between BRCA2/FancD1 and FancC in DNA repair. J Biol Chem. 2006;281:21312-20 pubmed
..that BRCA2-dependent chromatin loading of Rad51 after mitomycin C treatment was not compromised by disruption of FANCC or FANCD2. Rad51 and FancD2 form colocalizing subnuclear foci independently of each other...
Alpi A, Langevin F, Mosedale G, Machida Y, Dutta A, Patel K. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol. 2007;27:8421-30 pubmed
..FANCD2 monoubiquitination is therefore not regulated by multiprotein complex assembly but by the formation of an active E2/E3 holoenzyme on chromatin. ..
Mosedale G, Niedzwiedz W, Alpi A, Perrina F, Pereira Leal J, Johnson M, et al
. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol. 2005;12:763-71 pubmed
..Indeed, we found a genetic interaction between the FANCC and Hef genes...
Hirano S, Yamamoto K, Ishiai M, Yamazoe M, Seki M, Matsushita N, et al
. Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. EMBO J. 2005;24:418-27 pubmed
..SCE levels were elevated approximately 2-fold in chicken DT40 cells deficient in Fanconi anemia (FA) gene FANCC. To investigate the mechanism of the elevated SCE, we deleted FANCC in cells lacking Rad51 paralog XRCC3, TLS ..
Pace P, Mosedale G, Hodskinson M, Rosado I, Sivasubramaniam M, Patel K. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science. 2010;329:219-23 pubmed publisher
..We found a genetic interaction between the FA gene FANCC and the nonhomologous end joining (NHEJ) factor Ku70...