Gene Symbol: EGFR
Description: epidermal growth factor receptor
Alias: c-erbB, epidermal growth factor receptor, CER, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Nilsen T, Maroney P, Goodwin R, Rottman F, Crittenden L, Raines M, et al
. c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Cell. 1985;41:719-26 pubmed
..These results establish a novel pathway of promoter insertion oncogenesis that stands in contrast to the pathways used in the activation of c-myc in B lymphomas...
Chesters P, Howes K, Petherbridge L, Evans S, Payne L, Venugopal K. The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively. J Gen Virol. 2002;83:2553-61 pubmed
..Induction of both LL and ML by the two chimeric viruses occurred through the activation of c-myc, while the EB tumours were induced by activation of the c-erbB oncogene...
Omi M, Fisher M, Maihle N, Dealy C. Studies on epidermal growth factor receptor signaling in vertebrate limb patterning. Dev Dyn. 2005;233:288-300 pubmed
The epidermal growth factor receptor (EGFR) regulates multiple patterning events in Drosophila limb development, but its role in vertebrate limb morphogenesis has received little attention...
White P, Stone J, Groves A, Segil N. EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Dev Biol. 2012;363:191-200 pubmed publisher
..Here we show that in a subset of supporting cells marked by p75, EGFR signaling is required for proliferation, and this requirement is conserved between birds and mammals...
Flickinger T, Maihle N, Kung H. An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation. Mol Cell Biol. 1992;12:883-93 pubmed
At least four major transcripts are produced by the avian c-erbB/epidermal growth factor receptor gene. cDNAs corresponding to the smallest one, a 2.6-kb transcript, were isolated from an adult chicken liver cDNA library...
Goodwin R, Rottman F, Callaghan T, Kung H, Maroney P, Nilsen T. c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing. Mol Cell Biol. 1986;6:3128-33 pubmed
..Finally, blot hybridization evidence suggests that the two size classes of activated c-erbB mRNA in erythroblastic tissue represent truncated versions of the two c-erbB mRNAs present in normal tissue. ..
Lax I, Johnson A, Howk R, Sap J, Bellot F, Winkler M, et al
. Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha. Mol Cell Biol. 1988;8:1970-8 pubmed
..The differential binding and potency of mammalian EGF and TGF-alpha by the avian EGF receptor contrasts with the similar affinities of the mammalian receptor for the two growth factors. ..
Suh H, Lee Y, Han H. Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. J Cell Physiol. 2009;218:643-52 pubmed publisher
..In addition, IL-6 increased EGFR/src/FAK, PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG ..
Luo J, Chang S, Zhang H, Li B, Song J. DNA methylation down-regulates EGFR expression in chickens. Avian Dis. 2013;57:366-71 pubmed
The epidermal growth factor receptor (EGFR), a growth-factor-receptor tyrosine kinase, is up-regulated in numerous tumors, which provides a good target for cancer therapy...