DHFR

Summary

Gene Symbol: DHFR
Description: dihydrofolate reductase
Alias: dihydrofolate reductase
Species: chicken

Top Publications

  1. McTigue M, Davies J, Kaufman B, Kraut J. Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin. Biochemistry. 1992;31:7264-73 pubmed
    The 2.2-A crystal structure of chicken liver dihydrofolate reductase (EC 1.5.1.3, DHFR) has been solved as a ternary complex with NADP+ and biopterin (a poor substrate)...
  2. Kumar A, Blankenship D, Kaufman B, Freisheim J. Primary structure of chicken liver dihydrofolate reductase. Biochemistry. 1980;19:667-78 pubmed
    The complete covalent structure of dihydrofolate reductase from chicken liver is described. The S-carboxymethylated protein was subjected to cleavage by cyanogen bromide which produced five fragments...
  3. Fan Y, Ju M, Zhou J, Tsou C. Activation of chicken liver dihydrofolate reductase by urea and guanidine hydrochloride is accompanied by conformational change at the active site. Biochem J. 1996;315 ( Pt 1):97-102 pubmed
    It has been reported that the activation of dihydrofolate reductase (DHFR) from L1210 mouse leukaemia cells by KCl or thiol modifiers is accompanied by increased digestibility by proteinases [Duffy, Beckman, Peterson, Vitols and ..