CYP1A2

Summary

Gene Symbol: CYP1A2
Description: cytochrome P450, family 1, subfamily A, polypeptide 2
Alias: CYP1A5, CYPIA-2, CYPIA2, cytochrome P450 1A5, CYPIA5, cytochrome P450 TCDDAA
Species: chicken

Top Publications

  1. Gilday D, Gannon M, Yutzey K, Bader D, Rifkind A. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1996;271:33054-9 pubmed
    ..The findings further suggest that beyond their role in activating carcinogens, CYP1A enzymes have conferred evolutionary and developmental advantages, perhaps as defenses in maintaining homeostatic responses to toxic chemicals. ..
  2. Shang S, Jiang J, Deng Y. Chicken cytochrome P450 1A5 is the key enzyme for metabolizing T-2 toxin to 3'OH-T-2. Int J Mol Sci. 2013;14:10809-18 pubmed publisher
    ..We report that T-2 toxin significantly induces CYP1A4 and CYP1A5 expression in chicken embryonic hepatocyte cells...
  3. Murti J, Adiga P, Padmanaban G. Estradiol-17 beta induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver. Biochem Biophys Res Commun. 1991;175:928-35 pubmed
    ..The clone, pP-450 IA - 61, has an insert of 900nt and the sequence shows high homology to CYPIA2 subfamily from four other species...
  4. Sinclair P, Gorman N, Walton H, Sinclair J, Lee C, Rifkind A. Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney. Drug Metab Dispos. 1997;25:779-83 pubmed
    ..Two CYP enzymes induced by Ah receptor ligands were purified recently from chick embryo liver. One, designated CYP1A5, was preferentially active in arachidonic acid epoxygenation and the other, designated CYP1A4, in 7-..
  5. Zhang L, Zhang J, Guo K, Ji H, Zhang Y, Jiang S. Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res Vet Sci. 2011;90:99-105 pubmed publisher
    ..This suggested that high doses of enrofloxacin and marbofloxacin, but not sarafloxacin, inhibit CYP in chick liver raising the possibility of drug-drug interaction when using these compounds. ..
  6. Yang J, An J, Li M, Hou X, Qiu X. Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity. Comp Biochem Physiol C Toxicol Pharmacol. 2013;157:337-43 pubmed publisher
    ..Chickens have two CYP1A genes (CYP1A4 and CYP1A5) which are orthologous to mammalian CYP1A1 and CYP1A2. Although the importance of chicken CYP1As in metabolism of endogenous compounds and xenobiotics is well ..
  7. Yang J, Liu Z, Li M, Qiu X. Hydroxylation of quinocetone and carbadox is mediated by CYP1As in the chicken (Gallus gallus). Comp Biochem Physiol C Toxicol Pharmacol. 2013;158:84-90 pubmed publisher
    ..In this study, using bacteria produced enzymes, we demonstrated that both CYP1A4 and CYP1A5 participate in the oxidative metabolism of quinoxalines...