Gene Symbol: CYP1A1
Description: cytochrome P450, family 1, subfamily A, polypeptide 1
Alias: CYP1A4, CYP1A5, CYPIA4, CYPIA5, cytochrome P450 1A4, cytochrome P450 1A1, cytochrome P450 1A5, cytochrome P450 TCDDAA, cytochrome P450 TCDDAHH, cytochrome P450, family 1, subfamily A, polypeptide 4
Species: chicken

Top Publications

  1. Gilday D, Gannon M, Yutzey K, Bader D, Rifkind A. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1996;271:33054-9 pubmed
    ..ligand, leads in mammalian liver to the induction of genes for two distinct cytochrome P450 (CYP)1A enzymes, CYP1A1 and -1A2. Fish seem to have only one CYP1A enzyme...
  2. Li D, Wang M, Cheng S, Zhang C, Wang Y, Zhang W, et al. CYP1A1 based on metabolism of xenobiotics by cytochrome P450 regulates chicken male germ cell differentiation. In Vitro Cell Dev Biol Anim. 2017;53:293-303 pubmed publisher
    ..By knocking down CYP1A1, we detected the effect of CYP1A1-mediated metabolism of xenobiotics by cytochrome P450 on male germ cell ..
  3. Sinclair P, Gorman N, Walton H, Sinclair J, Lee C, Rifkind A. Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney. Drug Metab Dispos. 1997;25:779-83 pubmed
    ..One, designated CYP1A5, was preferentially active in arachidonic acid epoxygenation and the other, designated CYP1A4, in 7-ethoxyresorufin deethylase (EROD) and aryl hydrocarbon hydroxylase (AHH), reactions mainly catalyzed by ..
  4. Zhang L, Zhang J, Guo K, Ji H, Zhang Y, Jiang S. Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res Vet Sci. 2011;90:99-105 pubmed publisher
    ..blot analysis and real-time PCR were used to determine the effects on protein levels of CYP1A and 3A, and on CYP1A4, 1A5, 3A37 mRNA levels...
  5. Yang J, An J, Li M, Hou X, Qiu X. Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity. Comp Biochem Physiol C Toxicol Pharmacol. 2013;157:337-43 pubmed publisher
    ..Chickens have two CYP1A genes (CYP1A4 and CYP1A5) which are orthologous to mammalian CYP1A1 and CYP1A2...
  6. Yang J, Liu Z, Li M, Qiu X. Hydroxylation of quinocetone and carbadox is mediated by CYP1As in the chicken (Gallus gallus). Comp Biochem Physiol C Toxicol Pharmacol. 2013;158:84-90 pubmed publisher
    ..In this study, using bacteria produced enzymes, we demonstrated that both CYP1A4 and CYP1A5 participate in the oxidative metabolism of quinoxalines...